Troubles anxieux Archives - Bordeaux Neurocampus

Decision and adaptation (DECAD)

Mathieu Wolff — Thu, 07 Jun 2018 16:10:38 +0000

The scope of our team is to understand the neurobehavioral mechanisms involved in decision-making. This work relies on sophisticated behavioural paradigms understanding the action-outcome relationships in goal-directed responses. The originality of our research is to integrate cognitive neuroscience and behavioural psychology in rodent trained in complex operant tasks. The use of pharmacological and genetic tools implemented by meta-analyses allows us to reveal the neural circuits underlying behavioural flexibility and adapted behaviour. We characterised functional thalamic nuclei and identified a maturation period of the dopamine meso-prefrontal system during adolescence that may explain some form of impulsive behaviour observed during this period.…

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Ecological assessment and management of psychiatric disorders (ECOPSY)

Micha Pfeuty — Thu, 07 Jun 2018 16:10:50 +0000

The principal objective of our team is to combine advanced neuroimaging techniques and state-of-the-art mobile assessments of daily life behaviors, emotions and cognitive processes in order to understand the etiology and pathophysiology of CNS disorders. MRI allows for the characterization of neural networks involved in cognitive and emotional processes and their dysfunction, assessing the structural and functional integrity both of brain regions and the connections between regions of the brain network. Recent studies have also demonstrated the contribution of jointly using MRI and PET techniques, an approach which opens numerous new opportunities to identify structural and functional brain dysfunction and…

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Endocannabinoids and neuroadaptation

Giovanni Marsicano — Thu, 07 Jun 2018 16:10:38 +0000

Our team aims at uncovering the functions of the endocannabinoid system in the brain as well as the cannabinoids regulation of behavior and psychotic disorders. By using conditional mutagenesis, we are currently dissecting the roles of cannabinoid receptors type-1 (CB1) in different cellular and subcellular localizations towards a better understanding of the general rules governing behavior such as memory, locomotor activity and olfaction. Innovative techniques : mitochondrial dynamic and function assessment, voltage-sensitive dye imaging (VSDI), in vivo & ex vivo electrophysiology, transgenic mice, in situ hybridization.

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Neurogenesis and pathophysiology

Abrous D. Nora — Thu, 07 Jun 2018 16:10:22 +0000

Role of adult born neurons in memory, Adult neurogenesis and cognitive aging, Ontogeny of the hippocampus and hippocampal-dependent functions, Role of actin regulators in developmental and adult neurogenesis, State of the art behavioral paradigms, Innovative Techniques: Optogenetic in behaving rodents, In utero and postnatal electroporation, Retrovirus labeling of adult-born neurons in vivo, Retrograde monosynaptic rabies viral tracing system

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Pathophysiology of declarative memory

alineDesmedt — Thu, 07 Jun 2018 16:10:38 +0000

Our team aims at characterizing the neurobiological basis of addiction and molecular basis of traumatic memories. By applying a translational research, our work is dedicated to offer and develop new treatment Our aim is to identify psychobiological bases of declarative memory (DM) alterations occurring in aging and post-traumatic stress disorder (PTSD). We have developed specific behavioral models of age- and PTSD-related memory alterations in the mouse. Using these models, we search correlates of the cognitive changes at the system, cellular and molecular levels of brain activities. To establish causality links between neurobiological and cognitive changes, we then combine interventional approaches…

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Physiopathology and therapeutic approaches of stress-related diseases

Jean-Michel Revest — Thu, 07 Jun 2018 16:10:50 +0000

Our team aims at characterizing the neurobiological basis of addiction and molecular basis of traumatic memories. By applying a translational research, our work is dedicated to offer and develop new treatment for addiction. We successfully revealed neurobiological substrates involved in the transition to cocaine addiction. We recently demonstrated that pregnenolone can protect the brain from cannabis intoxication, that serves as a ground for clinical research. Innovative techniques: neurosteroids biochemistry, In vivo HPLC-microdialysis, model of addiction, rodent behavioral testing.

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