Troubles addictifs Archives - Bordeaux Neurocampus

Addiction, interoception and sex differences (NEED)

Céline Nicolas — Tue, 16 Apr 2024 14:38:36 +0000

For decades, neurosciences research was exclusively on males with the assumption that biological processes are the same across sexes. This dogma created a huge gap in our understanding of behavioral and brain mechanisms in both sexes. Although the field proved that this dogma is not always true, it left an important question unanswered: Why males and females have different vulnerability to brain disorders? Drug addiction is among the disorders with the highest men/women prevalence ratio. While the prevalence is higher in men, the gap between men and women is narrowing highlighting that drug addiction affects both sexes. Clinical and preclinical…

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Ecological assessment and management of psychiatric disorders (ECOPSY)

Micha Pfeuty — Thu, 07 Jun 2018 16:10:50 +0000

The principal objective of our team is to combine advanced neuroimaging techniques and state-of-the-art mobile assessments of daily life behaviors, emotions and cognitive processes in order to understand the etiology and pathophysiology of CNS disorders. MRI allows for the characterization of neural networks involved in cognitive and emotional processes and their dysfunction, assessing the structural and functional integrity both of brain regions and the connections between regions of the brain network. Recent studies have also demonstrated the contribution of jointly using MRI and PET techniques, an approach which opens numerous new opportunities to identify structural and functional brain dysfunction and…

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Emotion, Motivation and Cognition (EMOTIV)

vincentDavid — Thu, 07 Jun 2018 16:10:22 +0000

Our research is interested in the interactions between emotions and cognitive processes in normal conditions and pathological states (short and long-stress, aging, disease, addiction). Our main project aims at characterizing the neuronal substrates underlying the positive and negative emotion-memory interaction in normal young adult mice. We also study how the emotional impact on memory is altered by aging or in pathological states such as in Alzheimers disease, chronic alcohol and diencephalic dementia, to possibly restore the impaired memory functions. Innovative techniques: microdialysis, corticosterone assays, electrophysiology, rodent behavioural paradigms

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Endocannabinoids and neuroadaptation

Giovanni Marsicano — Thu, 07 Jun 2018 16:10:38 +0000

Our team aims at uncovering the functions of the endocannabinoid system in the brain as well as the cannabinoids regulation of behavior and psychotic disorders. By using conditional mutagenesis, we are currently dissecting the roles of cannabinoid receptors type-1 (CB1) in different cellular and subcellular localizations towards a better understanding of the general rules governing behavior such as memory, locomotor activity and olfaction. Innovative techniques : mitochondrial dynamic and function assessment, voltage-sensitive dye imaging (VSDI), in vivo & ex vivo electrophysiology, transgenic mice, in situ hybridization.

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Neural circuits of anxiety

Beyeler Anna — Thu, 07 Jun 2018 16:10:22 +0000

Fear can become elevated and continues in the absence of danger, becoming a psychiatric disorder called anxiety. Our research aims to highlight alterations in the neural circuits that control physiological fear in murine models of anxiety, through an analysis of connectivity, synaptic properties and gene expression profile. Our research is focused on insular cortex (insula) networks. This brain structure has been implicated in anxiety disorders by many functional imaging studies. We are also considering strategies to restore these alterations

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Neurogenesis and pathophysiology

Abrous D. Nora — Thu, 07 Jun 2018 16:10:22 +0000

Role of adult born neurons in memory, Adult neurogenesis and cognitive aging, Ontogeny of the hippocampus and hippocampal-dependent functions, Role of actin regulators in developmental and adult neurogenesis, State of the art behavioral paradigms, Innovative Techniques: Optogenetic in behaving rodents, In utero and postnatal electroporation, Retrovirus labeling of adult-born neurons in vivo, Retrograde monosynaptic rabies viral tracing system

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Psychobiology of vulnerability to drug addiction

Véronique Deroche-Gamonet — Thu, 07 Jun 2018 16:10:38 +0000

Our team works at the understanding of the psychobiological mechanisms of addiction, notably to cocaine and tobacco. Drug use can lead to behavioral disorders of which an extreme version is addiction. This psychopathology is not a mere excessive drug use, but is defined as a loss of control over use, which is particularly reflected in the maintenance of use despite its adverse effects. Critically, all users are not equally at risk for addiction, however. Our experimental strategy consists in integrating these characteristics of the pathology, i.e. loss of control over drug use and individual vulnerability, for an increased face and…

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Sleep, addiction and neuropsychiatry

Jean-Marc Alexandre — Thu, 07 Jun 2018 16:10:22 +0000

We study substance and non-substance addiction and have developed a human model of addiction. Our studies tend to better characterize the common phenomenology accross addictions and its determinants, using a multidisciplinary approach (clinical neurobiology, epidemiology, psychology and sociology), with a special interest on craving and its behavioral correlates. The main research tool is an open prospective cohort (ADDICTAQUI) started in 1994, of over 3500 patients requesting treatment for addiction. Innovative techniques: Patient prospective cohort, Addiction Severity Index, Ecological Momentary Assesment

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