Trafic intracellulaire Archives - Bordeaux Neurocampus

Dynamic organization and function of synapses

Daniel Choquet — Thu, 07 Jun 2018 16:10:22 +0000

Our team pursues a transdisciplinary approach, to study the interplay between the dynamics of the molecular components and the synaptic transmission. Based on advanced imaging techniques, we study AMPA receptors and its molecular partners. We obtained breakthrough data on nano-scale organization, dynamics and interaction of synaptic proteins and membrane trafficking, Our efforts are focused on the understanding of the synaptic components dynamics involved in higher cognitive functions and pathologies, such as Alzheimer disease. Innovative techniques | single particle tracking PALM, STORM, STED, live super resolution imaging, Patch-clamp

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Membrane traffic at synapses (MemTraS)

David Perrais — Fri, 03 Apr 2020 10:38:20 +0000

Our goal in the team is to study the mechanisms regulating synapse function, focusing on membrane trafficking events in normal brain physiology or in the course of disease. We are interested mainly in the presynaptic element filled with synaptic vesicles fusing to release neurotransmitter molecules as well as the post-synaptic side where post-synaptic receptors are going through cycles of endocytosis and recycling, which is essential for synaptic transmission and plasticity. Finally, we are not only interested in canonical synapses, such as cortical glutamatergic synapses, but also in rare and much less understood synapse populations such as neuromodulatory dopamine synapses. To…

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Physiopathology and therapeutic approaches of stress-related diseases

Jean-Michel Revest — Thu, 07 Jun 2018 16:10:50 +0000

Our team aims at characterizing the neurobiological basis of addiction and molecular basis of traumatic memories. By applying a translational research, our work is dedicated to offer and develop new treatment for addiction. We successfully revealed neurobiological substrates involved in the transition to cocaine addiction. We recently demonstrated that pregnenolone can protect the brain from cannabis intoxication, that serves as a ground for clinical research. Innovative techniques: neurosteroids biochemistry, In vivo HPLC-microdialysis, model of addiction, rodent behavioral testing.

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Planar polarity and plasticity

Nathalie Sans — Thu, 07 Jun 2018 16:10:38 +0000

Our group is interested in elucidating the role of the mammalian planar cell polarity (PCP) in the developing and adult nervous system. We study how defects in PCP genes cause sociability impairements and memory imbalances, typical of Autism spectrum disorder. To this goal, we explore the impact of PCP proteins (i.e. Vangl2 and Scrib1) on synaptic functions and characterise the PCP protein complexes and protein interactions. In parallel, we use the inner ear as a model to address the role and mechanisms of PCP signalling and identify novel molecular actors of PCP pathway. Innovative techniques: primary cultures of brain slices…

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Translational research in neurogenetic diseases (NRGEN)

giovanniBS — Mon, 03 Jan 2022 14:55:05 +0000

The team gathers together researchers interested in a continuum of overlapping neurogenetic disorders covering spinocerebellar degenerations (ataxias, spastic paraplegias), motor neuron diseases (amyotrophic lateral sclerosis, hereditary spastic paraplegias, neuropathies) and neurodegeneration with brain iron accumulations (NBIA). Our goal is to dissect the molecular bases of these neurogenetic diseases with the long-term goal of developing specific therapies, which are lacking for almost all of them. To this end, we use a combination of genetic analyses (exome, genome, repeat expansion detection), phenotype-genotype correlations, biomarker searches and functional analyses (cellular, yeast and mouse models).

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