Schizophrénie Archives - Bordeaux Neurocampus

Decision and adaptation (DECAD)

Mathieu Wolff — Thu, 07 Jun 2018 16:10:38 +0000

The scope of our team is to understand the neurobehavioral mechanisms involved in decision-making. This work relies on sophisticated behavioural paradigms understanding the action-outcome relationships in goal-directed responses. The originality of our research is to integrate cognitive neuroscience and behavioural psychology in rodent trained in complex operant tasks. The use of pharmacological and genetic tools implemented by meta-analyses allows us to reveal the neural circuits underlying behavioural flexibility and adapted behaviour. We characterised functional thalamic nuclei and identified a maturation period of the dopamine meso-prefrontal system during adolescence that may explain some form of impulsive behaviour observed during this period.…

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Developmental Brain Physiology and Pathology

Groc Laurent — Thu, 07 Jun 2018 16:10:38 +0000

A great challenge for our comprehension of brain development is to identify how biological signals (glutamate, monoamine, immune system, hormones) control the maturation of neuronal connections and brain circuit assemblies in healthy conditions as well as in psychotic disorders. In particular, we showed that the adaptation of developing excitatory synapses mainly depend on the dynamics of surface postsynaptic receptor, including the NMDA and AMPA receptor. Our team will combine cutting edge high resolution imaging and classical electrophysiological approaches to detect and decrypt the impact of auto-antibodies from psychotic patients. Innovative techniques: single-molecule imaging, receptor trafficking, ex vivo and in vivo…

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Ecological assessment and management of psychiatric disorders (ECOPSY)

Micha Pfeuty — Thu, 07 Jun 2018 16:10:50 +0000

The principal objective of our team is to combine advanced neuroimaging techniques and state-of-the-art mobile assessments of daily life behaviors, emotions and cognitive processes in order to understand the etiology and pathophysiology of CNS disorders. MRI allows for the characterization of neural networks involved in cognitive and emotional processes and their dysfunction, assessing the structural and functional integrity both of brain regions and the connections between regions of the brain network. Recent studies have also demonstrated the contribution of jointly using MRI and PET techniques, an approach which opens numerous new opportunities to identify structural and functional brain dysfunction and…

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Endocannabinoids and neuroadaptation

Giovanni Marsicano — Thu, 07 Jun 2018 16:10:38 +0000

Our team aims at uncovering the functions of the endocannabinoid system in the brain as well as the cannabinoids regulation of behavior and psychotic disorders. By using conditional mutagenesis, we are currently dissecting the roles of cannabinoid receptors type-1 (CB1) in different cellular and subcellular localizations towards a better understanding of the general rules governing behavior such as memory, locomotor activity and olfaction. Innovative techniques : mitochondrial dynamic and function assessment, voltage-sensitive dye imaging (VSDI), in vivo & ex vivo electrophysiology, transgenic mice, in situ hybridization.

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Neural Basis of Perception

Naoya Takahashi — Wed, 02 Sep 2020 09:55:02 +0000

Attention and contextual knowledge are prerequisites for optimal perception and decision making. The overarching goal of our lab is to achieve a mechanistic neural framework for cognitive control and contextual modulation of perception and behavioral actions. Towards this goal, our team focuses on tactile sensation, one of the most predominant sensory modalities in rodents to perceive the world. We investigate how tactile inputs are processed and modulated in mouse somatosensory cortex and then gated to the downstream regions. We hypothesize a canonical mechanism of input integration and transformation into spike trains in individual pyramidal neurons at different brain states (e.g.,…

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