Protein engineering Archives - Bordeaux Neurocampus https://www.bordeaux-neurocampus.fr/tag/protein-engineering/ Département de neurosciences de l’université de Bordeaux. Thu, 26 Mar 2026 14:58:52 +0000 fr-FR hourly 1 https://wordpress.org/?v=7.0.2 https://www.bordeaux-neurocampus.fr/wp-content/uploads/2018/03/cropped-favicon-neurocampus-512px-8bits-80x80.png Protein engineering Archives - Bordeaux Neurocampus https://www.bordeaux-neurocampus.fr/tag/protein-engineering/ 32 32 Dynamic organization and function of synapses https://www.bordeaux-neurocampus.fr/team/dynamic-organization-and-function-of-synapses/ Thu, 07 Jun 2018 16:10:22 +0000 https://neurodev-ng.u-bordeaux.fr/team/dynamic-organization-and-function-of-synapses/ Our team pursues a transdisciplinary approach, to study the interplay between the dynamics of the molecular components and the synaptic transmission. Based on advanced imaging techniques, we study AMPA receptors and its molecular partners. We obtained breakthrough data on nano-scale organization, dynamics and interaction of synaptic proteins and membrane trafficking, Our efforts are focused on the understanding of the synaptic components dynamics involved in higher cognitive functions and pathologies, such as Alzheimer disease. Innovative techniques | single particle tracking “PALM, STORM, STED”, live super resolution imaging, Patch-clamp

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]]> Structural Neurobiology, Interactions, and Protein Engineering of Receptors (SNIPER) https://www.bordeaux-neurocampus.fr/team/structural-biology-and-engineering-of-neuronal-proteins/ Mon, 07 Jan 2019 17:35:23 +0000 https://neurodev-ng.u-bordeaux.fr/?post_type=team&p=101421 The interests of our team lay at the interface of structural biology, protein engineering, and cellular neuroscience. We aim to understand molecular principles of neuronal signalling in health and disease, and to translate these to the cellular and organismal level. We use mammalian protein expression, protein chemistry, biophysical methods, X-ray crystallography and cryo-electron microscopy to study the interaction determinants and structures of synaptic protein complexes involved in neurodevelopmental disorders and neuronal disease. We use combinatorial methods and protein engineering to discover novel binders and manipulate protein sequence, structure and function, both to facilitate structural studies as well as enable therapeutic…

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