Dopamine Archives - Bordeaux Neurocampus

Emotion, Motivation and Cognition (EMOTIV)

vincentDavid — Thu, 07 Jun 2018 16:10:22 +0000

Our research is interested in the interactions between emotions and cognitive processes in normal conditions and pathological states (short and long-stress, aging, disease, addiction). Our main project aims at characterizing the neuronal substrates underlying the positive and negative emotion-memory interaction in normal young adult mice. We also study how the emotional impact on memory is altered by aging or in pathological states such as in Alzheimers disease, chronic alcohol and diencephalic dementia, to possibly restore the impaired memory functions. Innovative techniques: microdialysis, corticosterone assays, electrophysiology, rodent behavioural paradigms

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Membrane traffic at synapses (MemTraS)

David Perrais — Fri, 03 Apr 2020 10:38:20 +0000

Our goal in the team is to study the mechanisms regulating synapse function, focusing on membrane trafficking events in normal brain physiology or in the course of disease. We are interested mainly in the presynaptic element filled with synaptic vesicles fusing to release neurotransmitter molecules as well as the post-synaptic side where post-synaptic receptors are going through cycles of endocytosis and recycling, which is essential for synaptic transmission and plasticity. Finally, we are not only interested in canonical synapses, such as cortical glutamatergic synapses, but also in rare and much less understood synapse populations such as neuromodulatory dopamine synapses. To…

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