Dépression Archives - Bordeaux Neurocampus

Muriel Darnaudéry

CorinneJoffre — Sat, 28 Jul 2018 20:54:16 +0000

I am working on the hypothesis of the developmental origin of adult health and diseases using an integrative approach. My research is dedicated to the exploration of the role of early-life environment (nutrition, maternal obesity, maternal diabetes, maternal stress) on brain functions and vulnerability to neuropsychiatric diseases (depression, anxiety) in offspring using preclinical models. Our work indicates that adverse early-life events (both during pre- and postnatal periods) increase the allostatic load and program the brain vulnerability to stress later in life. I also explore the causal role of gut-brain dysfunctions (gut microbiota dysbiosis and gut leakiness) in the emergence of…

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Decision and adaptation (DECAD)

Mathieu Wolff — Thu, 07 Jun 2018 16:10:38 +0000

The scope of our team is to understand the neurobehavioral mechanisms involved in decision-making. This work relies on sophisticated behavioural paradigms understanding the action-outcome relationships in goal-directed responses. The originality of our research is to integrate cognitive neuroscience and behavioural psychology in rodent trained in complex operant tasks. The use of pharmacological and genetic tools implemented by meta-analyses allows us to reveal the neural circuits underlying behavioural flexibility and adapted behaviour. We characterised functional thalamic nuclei and identified a maturation period of the dopamine meso-prefrontal system during adolescence that may explain some form of impulsive behaviour observed during this period.…

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Developmental Brain Physiology and Pathology

Groc Laurent — Thu, 07 Jun 2018 16:10:38 +0000

A great challenge for our comprehension of brain development is to identify how biological signals (glutamate, monoamine, immune system, hormones) control the maturation of neuronal connections and brain circuit assemblies in healthy conditions as well as in psychotic disorders. In particular, we showed that the adaptation of developing excitatory synapses mainly depend on the dynamics of surface postsynaptic receptor, including the NMDA and AMPA receptor. Our team will combine cutting edge high resolution imaging and classical electrophysiological approaches to detect and decrypt the impact of auto-antibodies from psychotic patients. Innovative techniques: single-molecule imaging, receptor trafficking, ex vivo and in vivo…

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Dopamine and neuronal assemblies

Baufreton Jérôme — Thu, 07 Jun 2018 16:10:22 +0000

Our laboratory examines the functions of the « extended basal ganglia network », a neuronal network composed of interconnected limbic and motor nuclei. We aim at characterizing this network at the synaptic level, focusing on how synaptic transmission and plasticity are controlled by dopamine. Our research will provide new understandings of physiological functions (voluntary movements, associative learning) and of dopamine-associated disorders (Parkinsons disease, addiction). Innovative techniques: in vivo and ex vivo electrophysiology, single-cell labeling, optogenetic, neuronal tracing, neuropharmacology and viral mediated gene deliver

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Ecological assessment and management of psychiatric disorders (ECOPSY)

Micha Pfeuty — Thu, 07 Jun 2018 16:10:50 +0000

The principal objective of our team is to combine advanced neuroimaging techniques and state-of-the-art mobile assessments of daily life behaviors, emotions and cognitive processes in order to understand the etiology and pathophysiology of CNS disorders. MRI allows for the characterization of neural networks involved in cognitive and emotional processes and their dysfunction, assessing the structural and functional integrity both of brain regions and the connections between regions of the brain network. Recent studies have also demonstrated the contribution of jointly using MRI and PET techniques, an approach which opens numerous new opportunities to identify structural and functional brain dysfunction and…

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Emotion, Motivation and Cognition (EMOTIV)

vincentDavid — Thu, 07 Jun 2018 16:10:22 +0000

Our research is interested in the interactions between emotions and cognitive processes in normal conditions and pathological states (short and long-stress, aging, disease, addiction). Our main project aims at characterizing the neuronal substrates underlying the positive and negative emotion-memory interaction in normal young adult mice. We also study how the emotional impact on memory is altered by aging or in pathological states such as in Alzheimers disease, chronic alcohol and diencephalic dementia, to possibly restore the impaired memory functions. Innovative techniques: microdialysis, corticosterone assays, electrophysiology, rodent behavioural paradigms

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Nutrition and Neuropsychiatric Symptom Dimensions (NutriPsy)

CorinneJoffre — Thu, 07 Jun 2018 16:10:38 +0000

The aim of our research is to understand how Western-diet influences mood, well-being and cognition and can lead to neuropsychiatric disorders. As Western diet is characterized by low n-3 polyunsaturated fatty acid levels, we evaluate the role of lipid nutritional imbalance on brain remodeling, neuroimmune responses and emotional behavior. Innovative techniques | Lipid biochemistry, psychometric evaluation of behavior

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Purinergic mediated neuroinflammation and brain disorders

Boué-Grabot Eric — Thu, 24 Sep 2020 11:37:36 +0000

Neurological disorders rely on alterations of the central or peripheral nervous system that are caused by impairments of neuronal transmission or more global perturbations of local circuits that implicate glial cells. The scientific goal of our team is to understand the contribution of neuronal versus inflammatory signaling in brain disorders including amyotrophic lateral sclerosis (ALS), attention deficit/hyperactivity disorders (ADHD), chronic pain, and anxiety-related disorders. Our objectives are to determine (i) the contribution of purinergic signaling as a dual system, and (ii) the modulatory function of peptidergic signaling, both capable to regulate neuronal synaptic activation and microglial neuro-inflammatory reaction as well…

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