Alzheimer Archives - Bordeaux Neurocampus

Diplôme inter universitaire Maladies Neurodégénératives 2020-2021

Arnaud Rodriguez — Wed, 17 Jun 2020 11:50:29 +0000

A destination des professionnels paramédicaux. Les inscriptions sont ouvertes.

The post Diplôme inter universitaire Maladies Neurodégénératives 2020-2021 appeared first on Bordeaux Neurocampus.

G. Barthet et C. Mulle dans Progress in Neurobiology

Arnaud Rodriguez — Mon, 29 Jun 2020 16:42:02 +0000

Presynaptic failure in Alzheimer's disease

The post G. Barthet et C. Mulle dans Progress in Neurobiology appeared first on Bordeaux Neurocampus.

Computational and systems neuroscience

Gambino Frédéric — Thu, 07 Jun 2018 16:10:38 +0000

Neocortical function and plasticity underlie the remarkable adaptive skills of mammals. Among different projects, our team is studying how the prefrontal cortex computes and adapts its strategies through experience and learning to optimally select the sequence of actions that is expected to produce the most beneficial outcome. We developed an entirely in vivo multidisciplinary approach combining electrophysiology and functional imaging (intrinsic and voltage-sensitive dyes imaging), multiphoton laser-scanning microscopy, gene transfer and optogenetic during behavior in head-fixed and freely-moving mice. Innovative techniques: in vivo patch-clamp and optogenetic, chronic two-photon imaging during behavior. decision-making in virtual reality. high-dimentional analysis of brain circuit

The post Computational and systems neuroscience appeared first on Bordeaux Neurocampus.

IMN clinics

claireDLTTR — Mon, 03 Jan 2022 16:03:29 +0000

The clinical branch of the Institute of Neurodegenerative Diseases (IMNc) combines patient care (Expert Center for Parkinson’s disease, Dementia Clinic, French Reference Centre for Multiple System Atrophy, Competence Centre for Rare Dementia, Competence Centre for Tourette Syndrome) and clinical research in the fields of neurodegenerative diseases and movement disorders. Our research program builds on three axes. The first research axis investigates the pathophysiology of movement disorders and neurodegenerative diseases, focusing on dystonia, Tourette syndrome, gait, and tremor using both imaging and electrophysiological technics. The second research axis investigates the natural history of neurodegenerative disorders. It aims to determine factors of…

The post IMN clinics appeared first on Bordeaux Neurocampus.

Membrane traffic at synapses (MemTraS)

David Perrais — Fri, 03 Apr 2020 10:38:20 +0000

Our goal in the team is to study the mechanisms regulating synapse function, focusing on membrane trafficking events in normal brain physiology or in the course of disease. We are interested mainly in the presynaptic element filled with synaptic vesicles fusing to release neurotransmitter molecules as well as the post-synaptic side where post-synaptic receptors are going through cycles of endocytosis and recycling, which is essential for synaptic transmission and plasticity. Finally, we are not only interested in canonical synapses, such as cortical glutamatergic synapses, but also in rare and much less understood synapse populations such as neuromodulatory dopamine synapses. To…

The post Membrane traffic at synapses (MemTraS) appeared first on Bordeaux Neurocampus.

Pathophysiology of proteinopathies

Bezard Erwan — Thu, 07 Jun 2018 16:10:22 +0000

Our translational research is dedicated to uncovering the pathophysiology of Parkinsons disease and works towards development of therapeutic solutions. Our team is best known for its work on L-DOPA-induced dyskinesia (LID), serious motor complications associated to the chronic dopamine replacement therapy. Recently, we work on a collaborative project using innovative nanotechnology as a new means of imaging living systems and of delivering therapy. Innovative techniques: Optical nanoprobes, lysososomal targeted nanoparticles, kinematics, gene transfer, preclinical studies

The post Pathophysiology of proteinopathies appeared first on Bordeaux Neurocampus.

Sleep/Wake, Aging, Neuroimaging (SWAN)

ernestoSA — Sun, 30 Apr 2023 09:13:56 +0000

A core objective of our research is to examine the impact of sleep/wake disturbances on daytime functioning to elucidate the etiology and pathophysiology of age-related CNS disorders. Cognitive symptoms and physiological malfunctioning are assessed in clinical studies but also in population-based cohorts. We apply advanced neuroimaging techniques using multimodal approach coupling morphological and functional MRI techniques and dailylife assessment based on connected devices for sleep/wake cycle (actigraphic watch) and cognition (EMA on smart phone). More specifically, daily life evaluations unravel the intra-individual variability of physiological and cognitive functioning; we attempt to understand its anatomical and functional bases by analysing it…

The post Sleep/Wake, Aging, Neuroimaging (SWAN) appeared first on Bordeaux Neurocampus.

Synapses and neural circuits in behaviour

Mario Carta — Thu, 07 Jun 2018 16:10:38 +0000

The research carried out in our group ambitions to link cell biological mechanisms of proteins and lipids involved in glutamatergic synaptic function and dysfunction. Much of our work has focused on the roles of kainate receptors, a subject in which the group is internationally recognised. We elucidated new biophysical and pharmacological properties of kainate receptors in the developing hippocampal circuits and in temporal lobe epilepsy. Our group has also broken new ground with highly original work on the role of prostaglandins and other lipids in synaptic plasticity. Great efforts are made to develop new methods for investigating the connectivity and…

The post Synapses and neural circuits in behaviour appeared first on Bordeaux Neurocampus.