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Postdoctoral Position – Synchrotron Imaging Applied to Neurosciences

Environmental exposures to chemicals that injure the developing brain are among the known causes for the rise of neurodevelopmental disorders such as autism. Many autistic children have zinc deficiency, while in others an elevation of lead is observed, but the molecular mechanisms beyond this neurodevelopmental toxicity are unknown.

Aims

To investigate the hypothesis that zinc homeostasis and planar cell polarity (PCP) signaling pathway converge during the formation of the axon initial segment (AIS). We hypothesize that zinc dysregulation and/or lead exposure may negatively impact PCP signaling and AIS formation, thus impairing the establishment of neuronal polarity. Molecular remediation strategies will also be studied.

Tools

Live-cell fluorescence microscopy of proteins and synchrotron imaging of metals.

Skills

– PhD in Neurobiology, Biology, Biochemistry or related fields.
– experience in cell biology, confocal and/or synchrotron microscopy
– interest in the field of health/environmental research
– interest in innovative imaging techniques and data analysis
– ability to work meticulously
– ability to communicate and write in English

Work context

Host: Health/Environment, LP2iB, CNRS and University of Bordeaux, France.

Attractive working environment including state-of-the-art chemical imaging and neurobiology approaches in collaboration with Neurocenter Magendie. Synchrotron experiments will be carried out at specialized facilities in Europe.

Start date

February 2024, with flexibility depending on the candidate’s availability.

Contact

Please contact Richard Ortega () with CV and application letter.

Publication: 04/12/23
Mise à jour: 05/12/23