Post-doctoral position – team « Synaptic Circuits of Memory »

The project takes part in a collaborative translational effort to establish new therapies against temporal lobe epilepsy.

A post-doctoral position is open in the team of Christophe Mulle at the Institute for Interdisciplinary Neuroscience, CNRS, University of Bordeaux, France (http://www.iins.u-bordeaux.fr/research-teams-christophe-mulle?lang=en), within a vibrant neuroscience community. The project takes part in a collaborative translational effort to establish new therapies against temporal lobe epilepsy. The methods used by the post-doc will combine slice electrophysiology, cellular imaging, optogenetics and gene transfer in vivo. The post-doc will perform electrophysiological recordings (patch-clamp, fEPSPs) of pathological activities of rodent and human brain tissue in organotypic culture.

Profile: the candidate should have a solid background in Neuroscience, and hands-on experience in electrophysiological recordings and analysis. Language and writing English skills are also important.

Funding: a three year funding is available, starting as soon as possible.

Applications, including a CV, a detailed statement of skills and research interest, a list of publications, and 2-3 references, should be sent to: Christophe Mulle, CNRS Research Director, team leader, email: rf.xu1555817216aedro1555817216b-u@e1555817216llum.1555817216ehpot1555817216sirhc1555817216, Phone: +33(0)626016174.

Selection of recent publications of the group

1.     Carta M*, Lanore F*, Rebola N*, Szabo Z, Viana Da Silva S, Lourenço J, Verraes A, Nadler A, Schultz C, Blanchet C, Mulle C (2014) Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels. Neuron, 81:787–799.

2.     *Vergnano A, *Rebola N, *Savtchenko L, Pinheiro P, Kieffer B, Rusakov D, #Mulle C and #Paoletti P (2014). Zinc dynamics and action at excitatory synapses. #equal senior authors Neuron 82, 1101–1114.

3.     Viana da Silva, S., Haberl, M.G., Zhang, P., Bethge, P., Lemos, C., Gonçalves, N., Gorlewicz, A., Malezieux, M., Gonçalves, F.Q., Grosjean, N., Blanchet, C., Frick, A., Nägerl, U.V., Cunha, R.A., Mulle, C. (2016). Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors. Nature Communications 7, 11915.

4.     Fievre, S., Carta, M., Chamma, I., Labrousse, V., Thoumine, O., Mulle, C. (2016). Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells. Nature Communications 7, 12738.

5.     Zucca, S., Griguoli, M., Malezieux, M., Grosjean, N., Carta, M., Mulle, C. (2017). Control of Spike Transfer at Hippocampal Mossy Fiber Synapses In Vivo by GABAA and GABAB Receptor-Mediated Inhibition. J Neurosci 37, 587–598.

6.     Rebola, N., Carta, M., Mulle, C. (2017). Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding. Nat Rev Neurosci 18, 209–221 (review).

7.     Barthet, G., Jordà-Siquier, T., Rumi-Masante, J., Bernadou, F., Müller, U., Mulle, C., (2018). Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity. Nature Communications 1–14.

Last update: 14 mars 2019