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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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DTSTART;TZID=Europe/Paris:20230317T093000
DTEND;TZID=Europe/Paris:20230317T093000
DTSTAMP:20260510T072937
CREATED:20230106T135718Z
LAST-MODIFIED:20230216T105710Z
UID:154113-1679045400-1679045400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Hiromasa Takemura
DESCRIPTION:Hiromasa Takemura\nVenue: Centre Broca \n\nHiromasa Takemura\nNational Institute for Physiological Sciences\nOkazaki\, Japan\nhttps://www.nips.ac.jp/scbm/en/member/2021/08/HiromasaTakemura.html\nhttps://scholar.google.com/citations?user=ac6b5c8AAAAJ&hl=en \nInvited by Michel Thiebaut de Schotten \nTitle\nVisual field maps and white matter tracts in the human visual system \nAbstract\nOver the last several decades\, system neuroscience has made substantial progress in understanding brain functions by measuring response properties of individual brain regions and their relation to behavior. However\, it is not yet fully understood how such brain functions are related to the structural properties of the nervous system. To address unresolved question on structure-function relationship in the brain\, one needs to understand how functional organization of the brain is related to the neuroanatomy. The visual system is an ideal system to address such question since functional organization principle of visual areas\, such as visual field maps\, and anatomical connections between areas are relatively understood. In this talk\, I will describe recent studies investigating the relationship between functional organization of the visual areas and neuroanatomy of the visual system. First\, I will describe a recent study (Miyata et al.\, 2022) investigating a relationship between the size of the human primary visual cortex (V1) and the optic tract by analyzing fMRI and diffusion-weighted MRI (dMRI) in the Human Connective Project 7T Retinotopy dataset (Benson et al.\, 2018)\, based on hypothesis from a previous post-mortem study (Andrews et al.\, 1997). Second\, I will describe studies investigating the relationship between human extrastriate visual field maps (V3A/B and hV4) and the Vertical Occipital Fasciculus (VOF)\, which is a white matter tract connecting dorsal and ventral visual streams (Takemura et al.\, 2016). The analysis combining fMRI and dMRI suggests that the VOF is an important pathway for integration of upper and lower visual field information in the human visual system. In addition\, I will discuss that such finding can be extended into non-human primate visual system (Takemura et al.\, 2017; 2020). Finally\, I will briefly describe other recent projects in the lab\, such as a parcellation of the visual thalamus using quantitative MRI (Oishi et al.\, 2023) and comparative diffusion MRI on visual white matter pathways. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-hiromasa-takemura/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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DTSTART;TZID=Europe/Paris:20230317T140000
DTEND;TZID=Europe/Paris:20230317T140000
DTSTAMP:20260510T072938
CREATED:20230308T171554Z
LAST-MODIFIED:20230308T171911Z
UID:156843-1679061600-1679061600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Pierre Le Merre
DESCRIPTION:Venue: Neurocentre Magendie (conference room) \n\nPierre Le Merre\nCarlén Lab\nDepartment of Neuroscience | Karolinska Institutet\nSweden \nTitle\nFunctional maps of the mouse prefrontal cortex. \nAbstract\nThe mouse prefrontal cortex (PFC) lacks a definition. Further\, the function(s) of the PFC remains to be established\, regardless of species. Traditionally\, subregions of the PFC have been delineated based on cytoarchitectural features. Based on recent large-scale mapping of the connectivity of the mouse cortex\, a prefrontal module has been identified. The cortical subregions within this module (anterior cingulate (ACA)\, prelimbic area (PL)\, infralimbic area (ILA)\, orbitofrontal cortex (OFC)) display particularly high interconnectivity to each other than to other cortical regions. Hodology thus gives support for the presence of a distinct prefrontal region (module) in the mouse brain. However\, how hodology and cytoarchitectural features relate to function is highly unclear. We here use a series of behavioral auditory tasks and high-density (Neuropixels probes) recordings in a head-restrained mice to establish functional maps of the mouse PFC. Thousands of single units were recorded across the layers and the proposed subregions of the PFC. At first\, we extracted single unit features during spontaneous activity. We used functional connectivity and intrinsic timescales to establish a first hierarchical organization of PFC regions. We next used auditory stimuli to engage the subregions of the PFC while head-fixed mice passively listen to sounds or had to perform distinct behavioral tasks using the presented auditory stimuli. The presented data will focus on how functions segregate across the PFC during distinct behavioral auditory tasks\, and how different prefrontal functions relate to traditional delineations of the PFC based on cytoarchitecture and/or hodology. \nAbout Pierre Le Merre\nI am a postdoc in Marie Carlén’s lab in Stockhlom interested in understanding what cognition means in biological terms and how abstract cognitive variables are implemented by cortical networks and brain regions such as the prefrontal cortex (PFC). During my PhD\, I carried out two studies on cortical networks focusing on electrophysiological dynamics during behavioral states (Fernandez et al.\, 2017) and on their involvement in goal-directed sensorimotor transformations (Le Merre et al.\, 2018). To follow up on these findings\, I devoted my postdoc project to understand the richness of mouse prefrontal cortex electrophysiological activities. I specialized as an electrophysiologist\, performing high-density extracellular recordings (Neuropixels probes) combined with optogenetic tagging and perturbations. We recently submitted my first postdoc first author article (accessible on BioRXiv). My first author contribution to this study was to map activity signatures of aversive states in the mPFC. We are currently completing my second first author article revealing prefrontal functional differences during auditory processing with an unprecedented level of detail. We also wrote perspective article about the mouse prefrontal cortex to share our views and thoughts with the scientific community in a perspective article (Le Merre et al.\, 2021). \nI would like now to come back to France and start my own lab developing new approaches to study working memory (brain-wide activity\, voltage imaging) in the mouse. I am currently visiting different institutes to explore my comeback options. Bordeaux Neurocampus sounds like a perfect match and I would be honored to meet the scientific community and present my work to all interested researchers. \nhttps://www.pierrelemerre.com/ \nSelected publications:\nFernandez\, L.M.J.\, Comte\, J.-C.\, Le Merre\, P.\, Lin\, J.-S.\, Salin\, P.-A.\, and Crochet\, S. (2017). Highly Dynamic Spatiotemporal Organization of Low-Frequency Activities During Behavioral States in the Mouse Cerebral Cortex. Cereb Cortex 27\, 5444–5462. \nLe Merre\, P.\, Esmaeili\, V.\, Charriere\, E.\, Galan\, K.\, Salin\, P.-A.\, Petersen\, C.C.H.\, and Crochet\, S. (2018). Reward-Based Learning Drives Rapid Sensory Signals in Medial Prefrontal Cortex and Dorsal Hippocampus Necessary for Goal-Directed Behavior. Neuron 97\, 83-91.e5. \nLe Merre\, P.\, Ährlund-Richter\, S. and Carlén\, M. The mouse prefrontal cortex: Unity in diversity. Neuron 109\, (2021). \nCalvigioni D.*\, Fuzik J.*\, Le Merre P.*\, Slashcheva M.\, Jung F.\, Ortiz C.\, Lentini A.\, Csillag V.\, Graziano M.\, Nikolakopoulou I.\, Weglage M.\, Lazaridis I.\, Kim H.\, Lenzi I.\, Park H.\, Reinius B.\, Carl ́en\, M.\, Meletis\, K. Esr1+ hypothalamic-habenula neurons shape aversive states. (2022). BioRXiv. \n*equal contribution. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-pierre-le-merre/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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