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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190503T100000
DTEND;TZID=Europe/Paris:20190503T113000
DTSTAMP:20260605T051634
CREATED:20190305T114303Z
LAST-MODIFIED:20200316T134726Z
UID:103907-1556877600-1556883000@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire impromptu - Maxime Assous
DESCRIPTION:\n	\n		\n			Lieu : CGFB \n\nMaxime Assous\nMaxime ASSOUS\nCenter For Molecular and Behavioral Neurosciences\nRutgers University\nNewark\, New Jersey\, USA \nInvitants : Jérôme Baufreton / Nicolas Mallet\nIMN \n\n		\n	\n\n	\n		\n			Abstract\nThe classical view on striatal GABAergic interneuron function has been that they operate as independent\, parallel\, feed-forward inhibitory elements providing inhibitory inputs to SPNs. Much recent evidence has shown that the extrinsic innervation of striatal interneurons is not indiscriminate but rather very specific\, and that striatal interneurons are themselves interconnected in a cell-type-specific manner. This suggests that the impact of extrinsic inputs on striatal neuronal activity critically depends on synaptic interactions within interneuronal circuitry. For instance\, we recently described the existence of a striatal GABAergic interneuron population (Spontaneously Active Bursty Interneuron; SABIs)\, receiving cortical and thalamic innervation\, which does not seem to innervate the projection neurons\, indicating that it may represent the first interneuron-selective interneuron in striatum. Furthermore\, we recently showed that the most common response of low threshold spiking interneurons (LTSI) to thalamic stimulation is a disynaptic inhibition through thalamic activation of tyrosine hydroxylase-expressing interneurons (THINs). Further investigation of the excitatory innervation of striatal interneurons show cell-type specific disynaptic inhibitory responses after engagement of the cortex or the thalamus suggesting a high specificity and selectivity in the striatal microcircuitry. In addition\, our recent data suggest the existence of a novel source of glutamatergic innervation to the striatum\, originating in the pedunculopontine nucleus which selectively targets striatal interneurons\, inhibiting the striatal output via feedforward inhibition. Understanding the local striatal connectivity is fundamental to comprehend the integration of the different extrinsic inputs to the striatum. \nSelected publications :\nAssous M\, Faust TW\, Assini R\, Shah F\, Sidibe Y\, Tepper JM. (2018) Identification and Characterization of a Novel Spontaneously Active Bursty GABAergic Interneuron in the Mouse Striatum. J Neurosci. 2018 Jun 20;38(25):5688-5699. doi: 10.1523/JNEUROSCI.3354-17.2018. Epub 2018 May 22 \nAssous M\, Tepper JM. (2018) Excitatory extrinsic afferents to striatal interneurons and interactions with striatal microcircuitry. Eur J Neurosci. 2018 Feb 26. doi: 10.1111/ejn.13881. \nAssous M\, Kaminer J\, Shah F\, Garg A\, Koós T\, Tepper JM. (2017) Differential processing of thalamic information via distinct striatal interneuron circuits.Nat Commun. 2017 Jun 12;8:15860. doi: 10.1038/ncomms15860. \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-impromptu-maxime-assous/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190503T140000
DTEND;TZID=Europe/Paris:20190503T140000
DTSTAMP:20260605T051634
CREATED:20190427T133559Z
LAST-MODIFIED:20200316T134725Z
UID:106140-1556892000-1556892000@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire impromptu - Julia Lemos
DESCRIPTION:Lieu : Centre Broca Nouvelle-Aquitaine – Salle de conférence\n \n\nJulia Lemos\nDr. Julia Lemos\nAssistant Professor\nDepartment of Neuroscience – University of Minnesota (USA)\nhttps://www.lemoslaboratory.org/ \nInvitée par Anna Beyeler\nNeurocentre Magendie \n\nAbstract\nOutside of its well-characterized actions in the HPA axis\, the stress-associated peptide corticotropin-releasing factor (CRF) regulates neuronal excitability and synaptic transmission in several extrahypothalamic brain regions. Previous research has shown that CRF in the nucleus accumbens (NAc) promotes appetitive behavior through mechanisms that remain poorly understood. We have recently showed that CRF potentiates both dopaminergic and cholinergic transmission in the NAc. However\, it is unknown how CRF regulates the activity of medium spiny neurons (MSNs)\, the principle projection neurons of the NAc\, to modulate behavioral output. MSNs are classified by their peptide expression and projection targets within the basal ganglia: dMSNs form the direct projection pathway and express dynorphin\, whereas iMSNs form the indirect pathway and express enkephalin. RNAscope in situ hybridization was used to assess Crh1 mRNA expression in MSN subpopulations\, identifying dMSNs and iMSNs with expression of dynorphin (pdyn) or enkephalin (pEnk)\, respectively. 20% of all cells were positive for Crh1 mRNA\, with approximately 30% co-expressing pEnk mRNA (iMSNs)\, 30% co-expressing pDyn mRNA (dMSNs) and 30% co-expressing neither marker. Using whole-cell patch clamp electrophysiology recordings in brain slices\, we examined the function of exogenously-applied CRF on the excitability of MSNs in the NAc core. Application of 100 nM CRF produced a leftward shift in the current-voltage relationship\, demonstrating that CRF can enhance the firing rate of both dMSNs and iMSNs. Next steps will focus on identifying the role of CRF receptor subtypes in enhancing the spiking activity in MSNs and elucidate whether this effect is through direct actions on MSNs or through dopaminergic and cholinergic modulation of MSNs. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-julia-lemos/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190503T144500
DTEND;TZID=Europe/Paris:20190503T144500
DTSTAMP:20260605T051634
CREATED:20190429T083525Z
LAST-MODIFIED:20200316T134724Z
UID:106199-1556894700-1556894700@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire impromptu - Bernard Balleine
DESCRIPTION:Lieu : Centre Broca Nouvelle-Aquitaine – Salle de conférence \n\nBernard Balleine\nSchool of Psychology\nUNIVERSITY OF NSW\nKensington\nAustralia \nInvité par Mathieu Wolff – INCIA \nProfessor Balleine’s research aims to understand the neural bases of the learning and motivational processes that control volitional\, or goal-directed\, action\, an issue that has direct bearing on our developing understanding of the role that the integration of cognitive and emotional systems plays in executive functions and decision-making. Currently his research team is focusing on three primary issues: [1] The role of the prefrontal cortex-basal ganglia network in the changes in goal-directed learning that emerge as a consequence of neurodegeneration\, focal brain damage and addiction; [2] The role of the amygdala\, its brain stem afferents and its efferents on ventral striatum\, insular cortex and midbrain dopamine neurons in regulating the emotional processes through which the reward value of events is encoded; and [3] The role of the thalamo-striatal projection and related cortical connections involving somatosensory cortex in the integration of cognitive and emotional processes necessary for normal decision-making. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-impromptu-bernard-balleine/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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