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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20240913T113000
DTEND;TZID=Europe/Paris:20240913T113000
DTSTAMP:20260411T060434
CREATED:20240523T101658Z
LAST-MODIFIED:20240904T101603Z
UID:171712-1726227000-1726227000@www.bordeaux-neurocampus.fr
SUMMARY:EMBO global lecture - Felipe Barros
DESCRIPTION:Venue: Centre Broca \n\nFelipe Barros\nCenter for Scientific Studies (CECs) & Universidad San Sebastian (Valdivia\, Chile)\nhttps://researchers.uss.cl/es/persons/luis-felipe-barros-olmedo \nInvited by Ignacio Fernandez-Moncada and Giovanni Marsicano \nTitle\nLactate-carried Mitochondrial Energy Overflow \nAbstract\nLactate is a cytosolic metabolite and an extracellular signal that transfers carbons\, energy and information between cells and between organs. This EMBO Global lecture will present evidence of an additional role for lactate\, which involves mitochondria. \nUsing genetically-encoded fluorescent probes we observed that the mitochondrial matrix of every cell tested contains a dynamic lactate pool. In neurons\, mitochondrial lactate reported blood lactate fluctuations with high fidelity\, demonstrating high permeability of all membrane barriers interposed between plasma and the matrix. Passage across the inner mitochondrial membrane was found to be mediated by a high affinity H+-coupled transport system. Surprisingly\, pharmacological and genetic approaches revealed that this lactate permeability involves the mitochondrial pyruvate carrier MPC\, a transporter hitherto deemed specific for pyruvate. \nWhat is the (patho)physiological role of mitochondrial lactate? Determination of fluxes\, redox status and energization showed that mitochondria do not consume lactate. Rather\, they produce it. Strikingly\, lactate production was stimulated within seconds of exposure to hypoxia. \nWe propose that mitochondria produce lactate to modulate reductive stress and the ensuing production of reactive oxygen species\, a role reminiscent of that of uncoupling proteins. There are however some distinctions. Mitochondrial uncoupling consumes oxygen and discards the chemical energy of substrates irreversibly as heat. In contrast\, the present overflow mechanism spares oxygen and saves the energy in a form that can be recycled. \nRauseo et al.\, bioRxiv 2024. doi: https://doi.org/10.1101/2024.07.19.604361 \n
URL:https://www.bordeaux-neurocampus.fr/event/embo-seminar-felipe-barros/
CATEGORIES:A la une,Pour les scientifiques,Séminaire du vendredi
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