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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20250702T140000
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UID:179396-1751464800-1751464800@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Caroline Ménard
DESCRIPTION:Venue: Centre Broca \n\nCaroline Menard\, PhD\nDepartment of Psychiatry and Neuroscience\nFaculty of Medicine\, Université Laval\nCERVO Brain Research Center\nQuebec\, Canada\nWebsite: menardneurolab.com \nInvited by Nora Abrous (Magendie) \n\nTitle\nNeurovascular adaptations underlie stress vulnerability vs resilience in mice and human depression \nSummary\nOur research program aims to shed light on the biological mechanisms underlying stress vulnerability vs resilience\, with help of state-of-the-art photonic technology\, in order to develop innovative treatments and identify biomarkers of mood disorders. Our multidisciplinary approach combines behavioral experiments to functional\, cellular\, molecular\, and imaging studies and validation of our rodent findings in human samples. We showed that chronic stress exposure promotes blood-brain barrier hyperpermeability leading to passage of circulating inflammatory mediators into the brain and the establishment of depressive behaviors. These changes occur in a sex-specific manner which may contribute to sex differences in depression prevalence\, symptoms and treatment responses. \nRelevant publications\n\nDudek et al. (2025) Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood-brain barrier alterations\,  https://www.researchsquare.com/article/rs-2978353/v1\nDion-Albert et al. (2023) Neurovascular adaptations modulating cognition\, mood\, and stress responses\, Trends in Neurosciences\,  https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(23)00021-8\nDion-Albert et al. (2022) Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue\, Nature Communications\,  https://www.nature.com/articles/s41467-021-27604-x\nDudek et al. (2020) Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression\, PNAS\,  https://www.pnas.org/doi/10.1073/pnas.1914655117\nMenard et al. (2017) Social stress induces neurovascular pathology promoting depression\, Nature Neuroscience\, https://www.nature.com/articles/s41593-017-0010-3\n\n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-caroline-menard/
CATEGORIES:A la une,Magendie,Pour les scientifiques,Séminaire Impromptu
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