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DTSTART;TZID=Europe/Paris:20201106T113000
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CREATED:20200706T175253Z
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UID:123019-1604662200-1604665800@www.bordeaux-neurocampus.fr
SUMMARY:Conférence mensuelle (PhD seminar series) - Aline Desmedt
DESCRIPTION:Séminaire en ligne.\n \nL’adresse pour la visioconférence sera diffusé par email environ une semaine avant. \n\nAline Desmedt\nTeam « Pathophysiology of declarative memory »\nNeurocentre Magendie \nThe hippocampus at the core of PTSD-like memory\nPost-traumatic stress disorder (PTSD) is characterized by a paradoxical memory alteration with hypermnesia for salient traumatic cues and amnesia for the traumatic context. Clinical studies strongly suggest that a deficit in trauma contextualization would leave traumatic memory out of control and thus prone to be automatically reactivated upon trauma-related cues in any context through flashbacks. In this view\, recovery from PTSD-related hypermnesia would thus depend on recovery from contextual amnesia. Yet\, preclinical research focuses exclusively on the emotional hypermnesia\, leaving unexplored the putative causal role of a deficit in the hippocampus-dependent trauma contextualization in PTSD. \nUsing the first animal model that precisely recapitulates PTSD-related hypermnesia and amnesia\, we first show that compared to normal fear memory\, PTSD-like fear memory is specifically associated with hippocampal hypoactivation and neuronal alterations. Second\, we show that optogenetic inhibition of the hippocampus (dCA1) during stress can produce PTSD-like memory in mice\, whereas activating the dCA1 prevents its formation and promotes normal contextual fear memory. Finally\, trauma re-contextualization normalizes PTSD-like memory\, promoting the expression of a long-lasting normal fear memory. \nThese findings indicate that PTSD-like memory depends on contextual amnesia and that promoting the hippocampal function promotes a switch from PTSD-like to normal fear memory via trauma contextualization. Therefore\, these data call for promoting therapeutic approaches of PTSD centered on trauma contextualization and its underlying hippocampal mechanisms. \n
URL:https://www.bordeaux-neurocampus.fr/event/conference-mensuelle-phd-seminar-novembre2020/
CATEGORIES:A la une,Conférences mensuelles,Pour les scientifiques
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