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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20260329T010000
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DTSTART:20261025T010000
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DTSTART;TZID=Europe/Paris:20260522T113000
DTEND;TZID=Europe/Paris:20260522T113000
DTSTAMP:20260528T161227
CREATED:20250624T075616Z
LAST-MODIFIED:20260511T053640Z
UID:185242-1779449400-1779449400@www.bordeaux-neurocampus.fr
SUMMARY:PhD Seminar - Manuel Valero
DESCRIPTION:Venue: Centre Broca \n\nDr. Manuel Valero \nIMIM\, Barcelona\, Spain \nInvited by Julia Welte (Neurocentre Magendie) \nTitle\nCell-Type-Specific Inhibitory Mechanisms of Memory Reactivation \nAbstract\nMemories are thought to be consolidated through the reactivation of neuronal assemblies during high-frequency hippocampal events\, including sharp-wave ripples (SPW-Rs) and fast gamma oscillations. However\, the circuit mechanisms governing the formation and stabilization of these assemblies remain poorly understood. \nUsing silicon probes integrated with miniaturized LEDs\, we developed an approach to generate synthetic neuronal assemblies in vivo by selectively coactivating groups of CA1 pyramidal neurons in behaving mice. This approach allowed us to dissect the mechanisms underlying assembly formation in the hippocampus. \nOur results show that only high-frequency coactivation patterns induce persistent assembly formation and memory-reactivation-like dynamics\, despite other stimulation protocols producing similar levels of excitation. High-frequency stimulation uniquely recruits facilitating inhibitory responses mediated by specific interneuron populations\, including somatostatin and subsets of parvalbumin interneurons. The strength of inhibitory recruitment predicts the stabilization of induced assemblies and selectively suppresses competing activity patterns during subsequent sleep. \nFinally\, we present evidence suggesting that similar inhibitory mechanisms operate during naturally occurring learning-related assembly formation and memory reactivation\, supporting a broader role for inhibitory plasticity in organizing hippocampal population dynamics during memory consolidation. \nKey publications\nValero M†*\, Abad-Perez P†\, Gallardo A\, Picco M\, García-Hernandez R\, Brotons J\, Martínez-Félix A\, Machold R\, Rudy B\, Buzsáki G*.\nCooperative actions of interneuron families support the hippocampal spatial code.\nScience. 389\, 6764 (2025). \nValero M*\, Zutshi I\, Yoon E\, Buzsáki G*.\nProbing subthreshold dynamics of hippocampal neurons by pulsed optogenetics.\nScience. 375 (6580)\, 570-574 (2022). \nValero M\, Navas-Olive A\, Menendez de la Prida L\, Buzsáki G.\nInhibitory conductance controls place field dynamics in the hippocampus.\nCell Reports. 40 (8)\, 111232 (2022). \nMeet the speaker!\nYou are a research staff ? Write to Julia Goncalves who will organize the schedule. \nYou are a PhD student? You can register to share some pizza after the talk.  \n\nPhD seminars are organized by the NBA\, Bordeaux Neurocampus\, and the Bordeaux Neurocampus Graduate Program.  \n \n
URL:https://www.bordeaux-neurocampus.fr/event/phd-seminar-manuel-valero/
CATEGORIES:A la une,Conférences mensuelles,Magendie,Pour les scientifiques
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DTSTART;TZID=Europe/Paris:20260522T140000
DTEND;TZID=Europe/Paris:20260522T140000
DTSTAMP:20260528T161228
CREATED:20260121T131125Z
LAST-MODIFIED:20260513T070909Z
UID:191650-1779458400-1779458400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Vincent Breton-Provencher
DESCRIPTION:Venue: Centre Broca \n\nVincent Breton-Provencher\nUniversité Laval\, Canada\nhttps://vbplab.com/ \nInvited by Etienne Coutureau (INCIA) \nTitle\nDopaminergic and noradrenergic codes for reinforcement processing during learning \nSummary\nReinforcement learning relies on the brain’s ability to detect\, evaluate\, and respond to behaviourally relevant stimuli. This talk examines how two key neuromodulatory systems\, dopamine and noradrenaline\, contribute to this process. In the first part\, we show that dopamine does not simply signal reward prediction error\, but encodes a mixture of sensory intensity and outcome evaluation across anatomically distinct target regions. Using simultaneous fiber photometry recordings across the mPFC\, BLA\, NAc lateral shell\, and dorsal striatum\, we reveal that striatal regions prioritize outcome valuation\, while cortical and amygdalar regions are more sensitive to sensory salience\, suggesting a distributed and specialized dopaminergic code for reinforcement. In the second part\, we turn to noradrenaline and its role in gating cortical circuits during learning. We find that α1A adrenergic receptors\, concentrated in NDNF interneurons of motor cortex layer 1\, normally stabilize the circuit by dampening NDNF activity. Selective knockout of these receptors renders NDNF neurons hyperresponsive to movement and reward\, and disrupts the acquisition of cue-action-reward associations.These results suggest that noradrenaline\, acting through α1A receptors in layer 1\, gates the cortical circuit dynamics necessary for associative learning. Together\, these findings position dopamine and noradrenaline as complementary neuromodulatory systems that encode and gate reinforcement signals across distributed brain circuits to support learning. \nPublications\nBouchard\, S.J.\, Boutin\, J.\, Lévesque\, M.\, Breton-Provencher\, V. (2025) System-wide dissociation of reward and aversive dopaminergic signals. bioRxiv 2025.05. 27.656467 \nBreton-Provencher\, V.\, Drummond G.T.\, Feng\, J.\, Li\, Y.\, Sur\, M. (2022) Spatiotemporal dynamics of noradrenaline during learned behaviour. Nature 606 (7915)\, 732-738 \nBreton-Provencher\, V.\, Sur\, M. (2019) Active control of arousal by a locus coeruleus GABAergic circuit. Nature Neuroscience 29 (48)\, 15245-15257 \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-vincent-breton-provencher/
CATEGORIES:A la une,Pour les scientifiques,Séminaire du vendredi
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