BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260410T113000
DTEND;TZID=Europe/Paris:20260410T113000
DTSTAMP:20260410T104140
CREATED:20251016T134500Z
LAST-MODIFIED:20260402T114129Z
UID:188804-1775820600-1775820600@www.bordeaux-neurocampus.fr
SUMMARY:Friday seminar - Jeff Glennon
DESCRIPTION:Venue: Centre Broca \n\nJeff Glennon\nUniversity college Dublin\nhttps://people.ucd.ie/jeffrey.glennon \nInvited by Marc Landry (IMN) \nTitle\nThe sweet side of attention and compulsive behaviour\, an immunometabolic nexus regulated by K+ channels. \nAbstract\nAttention problems\, impulse control and compulsive behaviour are key behavioural elements common across both neurodevelopmental and neurodegenerative disorders. Building on large genetic data sets\, we ascertained that dysregulated insulin signaling leading to inflammatory challenges may be a converging mechanism. This has impacts on immunometabolic control and the proteome with K+ channels playing an important modulatory role. Within this presentation\, I will expand on our current mechanistic understanding and highlight novel strategies in modulating compulsivity and attention. \nRelevant publications:\n1) Insulin and disorders of behavioural flexibility. Sullivan M\, et al. Neurosci Biobehav Rev. 2023. PMID: 37059405\n2) Converging evidence points towards a role of insulin signaling in regulating compulsive behavior. van de Vondervoort IIGM\, et al. Transl Psychiatry. 2019. PMID: 31515486\n3) An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder. van de Vondervoort I\, et al. J Psychiatry Neurosci. 2016. PMID: 26854754\n4) Plasma neurology-related proteins associated with cognition are modulated by lifestyle in adults. Margara-Escudero HJ\, et al. EBioMedicine. 2025. PMID: 40972225\n5) Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time. Atucha E\, et al. Nat Neurosci. 2025. PMID: 40702323\n6) Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1. Nieuwenhuis S\, et al. Front Neurol. 2019. PMID: 31849810\n7) Blood Transcriptome Profiling Links Immunity to Disease Severity in Myotonic Dystrophy Type 1 (DM1). Nieuwenhuis S\, et al. Int J Mol Sci. 2022. PMID: 35328504 \n\nFriday seminars are organized with the support of Bordeaux Neurocampus \n
URL:https://www.bordeaux-neurocampus.fr/event/friday-seminar-jeff-glennon/
CATEGORIES:A la une,IMN,Pour les scientifiques,Séminaire du vendredi
END:VEVENT
END:VCALENDAR