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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20250330T010000
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DTSTART;VALUE=DATE:20250623
DTEND;VALUE=DATE:20250711
DTSTAMP:20260406T185837
CREATED:20250221T134407Z
LAST-MODIFIED:20250617T150657Z
UID:181014-1750636800-1752191999@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures : "The Brain Prize Course - Advanced Techniques for Synapse Biology"
DESCRIPTION:Venue : CARF \nOrganized by the Bordeaux School of Neuroscience. \nLectures are open to everyone. \nProgramme\nJune 24 – 9:00am \nCorette Wierenga (Radboud Universiteit\, Netherlansd)\nCoordination of excitatory and inhibitory synapses via dendritic endocannabinoid signaling. \nJune 24 – 11:00am \nFranck Polleux (Columbia University\, USA)\nSynaptic and molecular mechanisms underlying the emergence of feature selectivity in hippocampal neurons. \nJune 25 – 11:00am \nNelson Rebola (Institut du Cerveau\, France)\nNew insights into the cellular mechanisms regulating interneuron activity in the neocortex. \nJune 26 – 11:00am \nMonica Di Luca (Università degli Studi di Milano\, Italy)\nDynamic Synapses: local regulation and the long arm to the nucleus. \nJuly 7 – 9:00am\n Peter Scheiffele (Universität Basel\, Switzerland)\nMolecular mechanisms of neuronal circuit formation and plasticity. \nJuly 8 – 5:00pm \nMichael E. Greenberg (Harvard Medical School\, USA) – Virtual talk\nHonorary lecture – Brain Prize Winner\nHow nature and nurture conspire to control brain development and function. \nJuly 10 – 9:00am \nErin Schuman (Max Planck Institute for Brain Research\, Germany)\nHonorary lecture – Brain Prize Winner\nMessages and machines at neuronal synapses. \nJuly 10 – 11:00am \nPatrik Verstreken (VIB-KU Leuven Center for Brain & Disease Research\, Belgium)\nTargeting dementia by tackling synaptic Tau. \n\nCourse Directors\n– Cécile Charrier – Institut de Biologie de l’ENS\, France\n– Julien Dupuis – IINS – University of Bordeaux\, France \n\nMore details about the course \n
URL:https://www.bordeaux-neurocampus.fr/event/cajal-lectures-the-brain-prize-course-advanced-techniques-for-synapse-biology/
CATEGORIES:A la une,Cajal Lectures,Pour les scientifiques
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DTSTART;TZID=Europe/Paris:20250701T140000
DTEND;TZID=Europe/Paris:20250701T140000
DTSTAMP:20260406T185837
CREATED:20250513T093414Z
LAST-MODIFIED:20250526T093521Z
UID:183797-1751378400-1751378400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Henning Stahlberg
DESCRIPTION:Venue: Centre Broca \n \n\nHenning Stahlberg\nHenning Stahlberg\, Laboratory of Biological Electron Microscopy\, Institute of Physics\, School of Basic Sciences\, Federal Institute of Technology Lausanne (EPFL)\,\nDepartment of Fundamental Microbiology\, Faculty of Biology and Medicine\, University of Lausanne\, Switzerland. \nInvited by François Ichas \nTitle\nInvestigating Neurodegeneration in alpha-Synucleinopathies with Cryo-Electron Microscopy \nAbstract\nCryo-transmission electron microscopy (cryo-EM) or tomography (cryo-ET) of frozen hydrated specimens is an efficient technique for analyzing the structure of proteins or tissue sections. We study human brain tissue from patients who died from Parkinson’s disease or Alzheimer’s disease\, using high-pressure freezing\, sectioning and cryo-ET\, as well as correlative light and electron microscopy (CLEM). We also study alpha-synuclein fibrils\, which is the protein underlying Parkinson’s disease\, multiple system atrophy (MSA) and Dementia with Lewy bodies (DLB). Different fibril polymorphs will be presented and their potential impact on intracellular neurodegeneration mechanisms discussed. \nCryo-EM and cryo-ET suffer from a signal-to-noise ratio or recorded images. Contrast of cryo-EM can be improved through diffractive imaging. We employ a 4D-scanning transmission electron microscopy approach with parallax or ptychography data processing\, using an aberration-corrected Titan Krios. This 4D-STEM approach shows improved contrast of cryo-EM images. \n\nBurger et al.\, 1.94 Å structure of synthetic α-synuclein fibrils seeding MSA neuropathology\, bioRxiv 2024.07.01.601498;\ndoi: https://doi.org/10.1101/2024.07.01.601498\nShahmoradian et al.\, Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes. Nature Neuroscience 22\, 1099-1109 (2019)\nhttps://www.nature.com/articles/s41593-019-0423-2\nKüçükoğlu et al.\, Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution. Nature Commun. 15\, 8062 (2024).\nhttps://doi.org/10.1038/s41467-024-52403-5\n\nBiosketch\nProf. Henning Stahlberg’s research focuses on high-resolution cryo-electron microscopy techniques to study neurodegenerative diseases and other protein systems. He has contributed to the development of electron microscopy hardware and applications\, sample preparation\, data collection schemes\, and data analysis software systems. His team uses cryo-electron microscopy including 4D-STEM to study brain tissue from patients with Parkinson’s disease and other neurodegenerative conditions\, as well as the molecules involved in these diseases. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-henning-stahlberg/
CATEGORIES:A la une,IMN,Pour les scientifiques,Séminaire Impromptu
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