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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20240419T113000
DTEND;TZID=Europe/Paris:20240419T113000
DTSTAMP:20260506T032438
CREATED:20231130T182317Z
LAST-MODIFIED:20240412T133328Z
UID:165140-1713526200-1713526200@www.bordeaux-neurocampus.fr
SUMMARY:Friday seminar - Melanie Plourde
DESCRIPTION:Venue: Centre Broca \n\nMelanie Plourde\nUniversité de Sherbrooke\nCanada\nhttps://www.usherbrooke.ca/recherche/fr/specialistes/details/melanie.plourde2 \nInvited by Jean-Christophe Delpech (NutriNeuro) \nTitle\nUnderstanding the blood-to-brain link of omega-3 to better support brain health during aging. \nAbstract\nThe brain has high concentration of docosahexaenoic acid (DHA)\, a long chain omega-3 fatty acid (OM3). A diet rich in OM3 lower the risk of cognitive decline during aging although the mechanism is debated. However\, there is a consensus that OM3 need to cross within the brain by one of the three different barriers: the blood-brain-barrier (BBB)\, the blood cerebrospinal fluid (CSF) barrier or the blood arachnoid barrier\, an avascular barrier. During aging\, the BBB leaks and unwanted molecules can reach the brain\, thus promoting neuroinflammation and neuronal loss during aging and cognitive decline. The blood-CSF barrier is composed by the choroid plexus (ChP)\, acting as a physical barrier and secreting CSF\, neurotrophic proteins\, and removing toxic substances from the CSF. In a pilot project\, we performed lipidomic analysis of the mice ChP and found that it contains 3 times more arachidonic acid (ARA\, n-6) than DHA. ARA is a precursor of pro-inflammatory mediators. We also detected these pro-inflammatory mediators in the ChP and they increase during aging. Our team also found that the ChP lipidome can be modulated by OM3 dietary intake which change its transcriptomics. The next step of this program will be to focus on how the lipid composition of the barriers can modulate inflammation and generation of new neurons during aging. Altogether\, my team wants to provide evidence and a mechanistic explanation of how dietary omega-3 intake can modify brain cell functions and how they can help maintain brain functions during aging. \n  \n
URL:https://www.bordeaux-neurocampus.fr/event/friday-seminar-melanie-plourde/
CATEGORIES:A la une,Pour les scientifiques,Séminaire du vendredi
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DTSTART;TZID=Europe/Paris:20240419T140000
DTEND;TZID=Europe/Paris:20240419T140000
DTSTAMP:20260506T032438
CREATED:20240314T111449Z
LAST-MODIFIED:20240410T160504Z
UID:170022-1713535200-1713535200@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Alexander Mathis
DESCRIPTION:Venue: Centre Broca \n\nAlexander Mathis\nEPFL\, Lausanne\nhttps://scholar.google.com/citations?hl=en&user=Y1xCzE0AAAAJ \nInvited by Anna Beyeler (Magendie) \nTitle\nModeling sensorimotor circuits with machine learning: hypotheses\, inductive biases\, latent noise and curricula  \nAbstract\nHierarchical sensorimotor processing\, modularity and experience are all essential for adaptive motor control. Recent efficient musculoskeletal simulators and machine learning algorithms provide new computational approaches to gain insights into those concepts for biological motor control. Firstly\, I will present a hypothesis-driven modeling framework to quantitatively assess the computations underlying proprioception. We trained thousands of models to transform muscle spindle inputs according to 16 different hypotheses from the literature. For all those hypotheses\, we found that hierarchical models that better satisfy those hypotheses\, also explain neural recordings in the brain stem and cortex better. We furthermore find that models trained to estimate the state of the body are best at explaining neural data. Secondly\, I will discuss key methods (inductive biases\, latent exploration\, and curricula) to close the gap between reinforcement learning algorithms and biological motor control. Taken together\, these results highlight the importance of inductive biases\, and experience for biological motor control. \n  \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-alexander-mathis/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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