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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20220327T010000
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DTSTART:20221030T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20221010
DTEND;VALUE=DATE:20221027
DTSTAMP:20260410T135853
CREATED:20211029T154749Z
LAST-MODIFIED:20221028T143428Z
UID:140646-1665360000-1666828799@www.bordeaux-neurocampus.fr
SUMMARY:Cajal course - "Brain Organoids"
DESCRIPTION:Bordeaux School of Neuroscience \nMore details\nhttp://www.bordeaux-school-of-neuroscience.eu/trainings/cajal/cajal-2022/bo-2022/ \n
URL:https://www.bordeaux-neurocampus.fr/event/cajal-course-brain-organoids/
CATEGORIES:A la une,Cajal Lectures,Pour les scientifiques
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DTSTART;TZID=Europe/Paris:20221014T113000
DTEND;TZID=Europe/Paris:20221014T123000
DTSTAMP:20260410T135853
CREATED:20220211T181300Z
LAST-MODIFIED:20221010T153133Z
UID:144937-1665747000-1665750600@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire - Jaime de la Rocha
DESCRIPTION:Venue: Centre Broca \n\nJaime de la Rocha\nGroup Leader at IDIBAPS\nBarcelona\, Spain\nLab: www.braincircuitsbehavior.org\nCommunity: www.barccsyn.org \nInvited by Alexis Dubreuil\nTeam: Mallet/Leblois\, IMN \n\nTitle\nThe dynamics of evidence accumulation in expectation-guided perceptual decisions. \nAbstract\nPerceptual decisions require the integration of multiple sources of information over multiple time-scales. Ambiguous stimuli which vary in time require for instance fast accumulation of evidence\, a process largely studied but whose underlying mechanisms remain largely debated. Prior experiences on the other hand\, also impact the way we perceive the world by creating expectations\, a reference frame that can guide future decisions. Where in the brain these expectations are generated and where they are projected onto the space of possible decisions\, it still unknown. In this talk I will present data from rats performing two-alternative categorization tasks\, which require temporal integration within or/and across trials. First\, I will show that rats can leverage in across-trial correlations and consistently develop a tendency to repeat or alternate their previous response using an internal estimate of the sequence repeating probability. Second\, I will show that the timing and the orienting trajectory of their responses can be qualitatively explained by a novel model which\, building on the standard accumulation to evidence models\, incorporates proactive responses whose trajectories can be updated as the stimulus information reaches the decision bounds. Finally\, using this behavioral model\, pharmacological and optogenetic manipulations as well as electrophysiological recordings\, I will characterize the critical role of the associative striatum in this behavior. Together\, these results reveal that the accumulation of evidence across trials can exhibit complex dynamics and that the striatum plays a critical role in encoding this evidence and the choice biases it causes. \nKey publications\nIsolating perceptual biases caused by trial history during auditory categorization\nDaniel Duque and Jaime de la Rocha\nBioRxiv 2022.01.17.476581; doi: https://doi.org/10.1101/2022.01.17.476581 \nProactive and reactive accumulation-to-bound processes compete during perceptual decisions\nLluís Hernández-Navarro\, Ainhoa Hermoso-Mendizabal\, Daniel Duque\, Jaime de la Rocha*\, Alexandre Hyafil* (* equal contribution)\nNature Communictions\, 12(1)\, 1-15. 2021. \nFlexible categorization in perceptual decision making\nGenís Prat-Ortega\, Klaus Wimmer\, Alex Roxin* and  Jaime de la Rocha* (*equal contribution)\nNature Communications 12\, 1283\, 2021. \nEcologically pre-trained RNNs explain suboptimal animal decisions\nManuel Molano-Manzón\, Yuxiu Shao\, Daniel Duque\, Guangyu Robert Yang\, Srdjan Ostojic and Jaime de la Rocha\nBioRxiv. 2022 Jan 1:2021-05. \nResponse outcomes gate the impact of expectations on perceptual decisions \nAinhoa Hermoso-Mendizabal*\, Alexandre Hyafil*\, Pavel E. Rueda-Orozco\, Santiago Jaramillo\, David Robbe\, Jaime de la Rocha (*equal contribution)\nNature Communications 11\, 1057\, 2020 \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-jaime-de-la-rocha/
CATEGORIES:A la une,Pour les scientifiques,Séminaire du vendredi
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