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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20220327T010000
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DTSTART:20221030T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20221010
DTEND;VALUE=DATE:20221027
DTSTAMP:20260410T120917
CREATED:20211029T154749Z
LAST-MODIFIED:20221028T143428Z
UID:140646-1665360000-1666828799@www.bordeaux-neurocampus.fr
SUMMARY:Cajal course - "Brain Organoids"
DESCRIPTION:Bordeaux School of Neuroscience \nMore details\nhttp://www.bordeaux-school-of-neuroscience.eu/trainings/cajal/cajal-2022/bo-2022/ \n
URL:https://www.bordeaux-neurocampus.fr/event/cajal-course-brain-organoids/
CATEGORIES:A la une,Cajal Lectures,Pour les scientifiques
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DTSTART;TZID=Europe/Paris:20221012T110000
DTEND;TZID=Europe/Paris:20221012T110000
DTSTAMP:20260410T120917
CREATED:20220928T152924Z
LAST-MODIFIED:20221005T135421Z
UID:151109-1665572400-1665572400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Sepand Rastegar
DESCRIPTION:Venue: Centre Broca \n\nSepand Rastegar\nKarlsruhe Institute of Technology\nhttps://bip.ibcs.kit.edu/rastegar.php \nInvited by Karine Massé \nTitle\nControl of adult neurogenesis and regeneration by the BMP-Id1 signalling pathway in the adult zebrafish telencephalon. \nAbstract\nNeurons are the building blocks of all nervous systems. In mammals\, neurons are generally not replaced when damaged or dead\, which can lead to progressive degeneration and death of neuronal tissues\, resulting in neurological disorders.\nIn contrast\, teleost fish have the remarkable ability to generate new neurons and repair damage\, even as adults. We are therefore using zebrafish as a model to understand when\, where and how adult neurogenesis functions in these fish and how it differs from the situation in mammals.\nDuring neurogenesis\, multiple developmental decisions lead to the establishment of specific transcriptional expression programmes\, and these programmes are controlled by the expression and/or selective activity of transcriptional regulators.\nTo understand the molecular mechanisms that control adult neurogenesis and regeneration\, we performed a genome-wide screen to find transcriptional regulators expressed in the adult zebrafish brain and their response to injury. We identified several hundred transcriptional regulatory genes whose expression is altered by injury. Among these genes\, the expression of id1 (DNA binding inhibitor 1) was upregulated specifically in the ventricular zone of injured brains.\nIn my talk\, I will present our latest results concerning the function of id1 and its transcriptional regulation during adult constitutive and regenerative neurogenesis in the zebrafish telencephalon. I will show how radial glia neuron-cell communication via BMP/Id1 signalling is essential for the long-term maintenance of regenerative capacity in the adult zebrafish telencephalon. \n\n10 recent publications\n\nBaranasic D\, Hörtenhuber M\, Balwierz PJ\, Zehnder T\, Mukarram AK\, Nepal C\, Várnai C\, Hadzhiev Y\, Jimenez-Gonzalez A\, Li N\, Wragg J\, D’Orazio FM\, Relic D\, Pachkov M\, Díaz N\, Hernández-Rodríguez B\, Chen Z\, Stoiber M\, Dong M\, Stevens I\, Ross SE\, Eagle A\, Martin R\, Obasaju O\, Rastegar S\, McGarvey AC\, Kopp W\, Chambers E\, Wang D\, Kim HR\, Acemel RD\, Naranjo S\, Łapiński M\, Chong V\, Mathavan S\, Peers B\, Sauka-Spengler T\, Vingron M\, Carninci P\, Ohler U\, Lacadie SA\, Burgess SM\, Winata C\, van Eeden F\, Vaquerizas JM\, Gómez-Skarmeta JL\, Onichtchouk D\, Brown BJ\, Bogdanovic O\, van Nimwegen E\, Westerfield M\, Wardle FC\, Daub CO\, Lenhard B\, Müller F. Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements. Nat Genet. 2022 Jul;54(7):1037-1050. doi: 10.1038/s41588-022-01089-w.\nLübke L\, Zhang G\, Strähle U\, Rastegar S. mdka Expression Is Associated with Quiescent Neural Stem Cells during Constitutive and Reactive Neurogenesis in the Adult Zebrafish Telencephalon. Brain Sci. 2022 Feb 18;12(2):284. doi: 10.3390/brainsci12020284.\nZhang G\, Lübke L\, Chen F\, Beil T\, Takamiya M\, Diotel N\, Strähle U\, Rastegar S. Neuron-radial glial cell communication via BMP/Id1 signaling maintains the regenerative capacity of the adult zebrafish telencephalon. Cells. 2021 Oct 19;10(10):2794. doi: 10.3390/cells10102794.\nGourain V\, Armant O\, Lübke L\, Diotel N\, Rastegar S\, Strähle U. Multi-dimensional transcriptome analysis reveals modulation of cholesterol metabolism as highly integrated response to brain injury. Front Neurosci. 2021 May 14;15:671249. doi: 10.3389/fnins.2021.671249. eCollection 2021.\nGhaddar\, B.\, Lübke\, L.\, Couret\, D.\, Rastegar S#.\, Diotel\, N. (2021) Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury. Cells. 2021 Feb 14;10(2):391. doi: 10.3390/cells10020391.\nDiotel\, N.\, Lübke\, L.\, Strähle\, U.\, Rastegar\, S. (2020) Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals. Frontiers in neuroscience. Front Neurosci. 2020 Sep 23;14:568930.doi: 10.3389/fnins.2020.568930. eCollection 2020.\nPax6 organizes the anterior eye segment by guiding two distinct neural crest waves.Takamiya M\, Stegmaier J\, Kobitski AY\, Schott B\, Weger BD\, Margariti D\, Cereceda Delgado AR\, Gourain V\, Scherr T\, Yang L\, Sorge S\, Otte JC\, Hartmann V\, van Wezel J\, Stotzka R\, Reinhard T\, Schlunck G\, Dickmeis T\, Rastegar S\, Mikut R\, Nienhaus GU\, Strähle U. PLoS Genet. 2020 Jun 17;16(6):e1008774. doi: 10.1371/journal.pgen.1008774.\nZhang G\, Ferg M\, Lübke L\, Takamiya M\, Beil T\, Gourain V\, Diotel N\, Strähle U\, Rastegar S. Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module. Stem Cells. (2020) Apr 3. doi: 10.1002/stem.3182.\nRastegar\, S.\, Parimisetty\, A.\, Cassam-Sulliman\, N.\, Narra Sai\, S.\, Weber\, S.\, Rastegar\, M.\, Viranaicken\, W.\, Couret\, D.\, Planesse\, C.\, Strähle\, U.\, Meilhac\, O.\, Lefebvre d’Hellencourt\, C.\, Diotel\, N. (2019) Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair. The Journal of comparative neurology. 527(14):2317-2333.\nGerber V\, Yang L\, Takamiya M\, Ribes V\, Gourain V\, Peravali R\, Stegmaier J\, Mikut R\, Reischl M\, Ferg M\, Rastegar S#\, Strähle U. The HMG box transcription factors Sox1a and b specify a new class of glycinergic interneurons in the spinal cord of zebrafish embryos. Development. 2019 Feb 20;146(4). pii: dev172510. doi: 10.1242/dev.172510.\n\n  \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-12-october-sepand-rastegar/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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