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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20200207T083000
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DTSTAMP:20260503T140639
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SUMMARY:Stand commercial : Eurobio Scientific
DESCRIPTION: \n
URL:https://www.bordeaux-neurocampus.fr/event/stand-commercial-eurobio-scientific/
CATEGORIES:A la une,Stand ou séminaire commercial
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DTSTART;TZID=Europe/Paris:20200207T103000
DTEND;TZID=Europe/Paris:20200207T113000
DTSTAMP:20260503T140639
CREATED:20200117T133601Z
LAST-MODIFIED:20200316T134707Z
UID:115052-1581071400-1581075000@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire impromptu - Alexei Vyssotski
DESCRIPTION:Lieu : CGFB \n\nElectrophysiological and behavioral monitoring in free-moving animals \nDr Alexei Vyssotski\nDr Alexei Vyssotski\nETHZ \, Zurich\nhttp://www.vyssotski.ch/ \nInvité par Jérôme Badaut (INCIA) \n\nAbstract\nEvolution of cognition remains one of the main mysteries of modern science. Social interactions are thought to be one of the major factors accelerating cognitive evolution. While social behaviors are supported by highly developed sophisticated brain structures\, developing of evolutionary pleasurable models explaining animal behavior needs the analysis of brain activity in ecological context\, in the animals involved in their natural social behavior. \nTo access brain activity during natural behaviors we have developed a set of wearable logging devices called Neurologgers. The latest Neurologger 3 is capable to record up to 64 neuronal channels into its up to 1TB memory and is small enough to be placed on the head of a small animal such as a mouse. \nThe main obstacle for investigating vocal interactions in vertebrates is the difficulty of discriminating individual vocalizations of rapidly moving\, sometimes simultaneously vocalizing individuals. We developed a method of recording and analyzing individual vocalizations in free-ranging animals using ultraminiature back-attached sound and acceleration recorders. Our method allows the separation of zebra finch vocalizations irrespective of background noise and the number of vocalizing animals nearby\, helping to reveal hierarchical network of vocalizations in songbird groups. \nThe recording of brain activity in freely flying navigating homing pigeons helps to reveal which navigation-relevant visual cues attract most of attention. The decreased brain activation by these stimuli in the flock-flying birds can be associated with decreased individual information processing in the case of collective decision making. The development of high-accuracy indoor tracking helps to address social interactions and collective decision making in a controllable environment. \nHowever\, not only comprehensive behavioral readout is needed\, but also precisely localized brain activity. This makes the reliable long-lasting neural recording an emerging necessity. Recently developed ultra-thin flexible multichannel neural probes allow us to track activity of isolated cells up to 40 days. The combination of flexible electrodes with our Neurologgers may be a promising approach for days-long neural recording in freely moving animals in their natural environments. \nSelected publications\nVyssotski AL\, Stepien AE\, Keller GB\, Hahnloser RH. (2016) A neural code that is isometric to vocal output and correlates with its sensory consequences. PLoS Biol. 2016 Oct 10;14(10):e2000317. doi: 10.1371/journal.pbio.2000317. \nRattenborg NC\, Voirin B\, Cruz SM\, Tisdale R\, Dell’Omo G\, Lipp HP\, Wikelski M\, Vyssotski AL. (2016) Evidence that birds sleep in mid-flight. Nat Commun. 2016 Aug 3;7:12468. doi: 10.1038/ncomms12468. \nAnisimov VN\, Herbst JA\, Abramchuk AN\, Latanov AV\, Hahnloser RH\, Vyssotski AL (2014) Reconstruction of vocal interactions in a group of small songbirds. Nat Methods. 2014 Nov; 11(11):1135-7. doi: 10.1038/nmeth.3114. \nVyssotski AL\, Dell’Omo G\, Dell’Ariccia G\, Abramchuk AN\, Serkov AN\, Latanov AV\, Loizzo A\, Wolfer DP\, and Lipp H-P (2009) EEG responses to visual landmarks in flying pigeons. Curr Biol. 19(14): 1159-1166. \nVyssotski AL\, Serkov AN\, Itskov PM\, Dell’Omo G\, Latanov AV\, Wolfer DP\, and Lipp H-P (2006) Miniature neurologgers for flying pigeons: multichannel EEG and action and field potentials in combination with GPS recording. J Neurophysiol 95: 1263-1273. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-impromptu-alexei-vyssotski/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20200207T113000
DTEND;TZID=Europe/Paris:20200207T113000
DTSTAMP:20260503T140639
CREATED:20190227T171034Z
LAST-MODIFIED:20200316T133440Z
UID:103776-1581075000-1581075000@www.bordeaux-neurocampus.fr
SUMMARY:Conférence mensuelle (PhD seminar series) - Tara Spires Jones
DESCRIPTION:Vendredi 7 février à 11h30  \nLieu : Centre Broca Nouvelle-Aquitaine \nTara Spires Jones\nPersonal Chair of Neurodegeneration\nDeputy Director of the Centre for Discovery Brain Sciences\nhttps://www.ed.ac.uk/ \nInvitée par Bordeaux Neurocampus et la NBA \n\nAbstract\nSynapse loss correlates strongly with cognitive decline in Alzheimer’s disease\, but the mechanisms underpinning this phenomenon remain unclear. In our group\, we have evidence from mouse models and human post mortem brain tissue implicating pathological proteins in synapse degeneration mediated by interactions between neurons and glia. In a transgenic mouse model of Alzheimer’s disease\, behavioural changes are accompanied by accumulation of amyloid beta and tau in synapses\, increases in inflammatory gene expression\, and phagocytosis of synapses by microglia. When soluble tau levels were lowered\, tau in synapses was reduced and the behavioural phenotype and inflammatory gene expression changes recovered. In human AD brain\, we observe similar accumulations of pathological amyloid beta and tau in synapses\, increases in proteins involved in microglial inflammation\, and increased microglial ingestion of synaptic proteins compared to control brain. Together\, our data implicate pathological protein accumulation in synapses may contribute to synapse phagocytosis by microglia. \nSelected Publications\nTzioras M\, Daniels MJD\, King D\, Popovic K\, Holloway RK\, Stevenson AJ\, Tulloch J\, Kandasamy J\, Sokol D\, Latta C\, Rose J\, Smith C\, Miron VE\, HEnstridge CM\, McColl BW\, Spires-Jones TL (2019) Altered synaptic ingestion by human microglia in Alzheimer’s disease. bioRxiv  https://doi.org/10.1101/795930 \nPickett EK\, Herrmann AG\, McQueen J\, Abt K\, Dando O\, Tulloch J\, Jain P\, Dunnett S\, Sohrabi S\, Fjeldstad MP\, Calkin W\, Murison L\, Jackson RJ\, Tzioras M\, Stevenson A\, d’Orange M\, Hooley M\, Davies C\, Colom-Cadena M\, Anton-Fernandez A\, King D\, Oren I\, Rose J\, McKenzie CA\, Allison E\, Smith C\, Hardt O\, Henstridge CM\, Hardingham GE\, Spires-Jones TL (2019) Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease. Cell Rep 29: 3592-3604 e3595 Doi 10.1016/j.celrep.2019.11.044; \nJackson RJ\, Rose J\, Tulloch J\, Henstridge C\, Smith C\, Spires-Jones TL (2019) Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers. Brain Commun 1: fcz003 Doi 10.1093/braincomms/fcz003; \nHesse R\, Hurtado ML\, Jackson RJ\, Eaton SL\, Herrmann AG\, Colom-Cadena M\, Tzioras M\, King D\, Rose J\, Tulloch J\, McKenzie CA\, Smith C\, Henstridge CM\, Lamont D\, Wishart TM\, Spires-Jones TL (2019) Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype. Acta Neuropathol Commun 7: 214 Doi 10.1186/s40478-019-0847-7; \nHenstridge CM\, Hyman BT\, Spires-Jones TL (2019) Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nat Rev Neurosci 20: 94-108 Doi 10.1038/s41583-018-0113-1 \nAbout the speaker\nProfessor Tara Spires-Jones\, DPhil\nUK Dementia Research Institute Programme Lead\nDeputy Director\, Centre for Discovery Brain Sciences\nThe University of Edinburgh\n\nFounding Editor Brain Communications\nSection Editor European Journal of Neuroscience\nBoard of Reviewing Editors Science\nEditorial Board Member Cell Reports\n\n\nTwitter @TSpiresJones\n\n
URL:https://www.bordeaux-neurocampus.fr/event/conference-mensuelle-tara-spires-jones/
CATEGORIES:A la une,Conférences mensuelles,Pour les scientifiques
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