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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20230326T010000
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DTSTART:20231029T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20230916
DTEND;VALUE=DATE:20240617
DTSTAMP:20260422T222014
CREATED:20230831T131841Z
LAST-MODIFIED:20240529T183441Z
UID:162040-1694822400-1718582399@www.bordeaux-neurocampus.fr
SUMMARY:Exposition : Cervorama
DESCRIPTION:Agitez vos neurones ! \nA travers cette exposition\, Cap Sciences propose aux visiteurs de découvrir le cerveau sous toutes ses formes lors d’une visite ponctuée de manipulations\, de jeux et d’expériences… Ils pourront notamment explorer les mondes des cerveaux de l’escargot\, l’abeille\, le singe et l’homme\, tester leur mémoire dans le « cognitilab »\, découvrir leur cerveau en 3D grâce au cervomaton ou encore analyser les capacités des animaux ! \nUne exposition conçue et réalisée par Cap Sciences en partenariat avec Bordeaux Neurocampus\n \nEn savoir plus\nSite web : https://www.cap-sciences.net/au-programme/exposition/grand-public/cervorama/ \n
URL:https://www.bordeaux-neurocampus.fr/event/exposition-cervorama/
CATEGORIES:Evénements pour tous,not-calendar,pour tous homepage,Semaine du cerveau 2024
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20240517
DTEND;VALUE=DATE:20240519
DTSTAMP:20260422T222014
CREATED:20240207T212008Z
LAST-MODIFIED:20240425T081057Z
UID:167820-1715904000-1716076799@www.bordeaux-neurocampus.fr
SUMMARY:3rd BPAN disease symposium in France
DESCRIPTION:The University of Bordeaux and the Association Autour du BPAN gather to organize the third symposium on BPAN disease in Bordeaux\, France. This international symposium will bring together patient organization\, scientific and medical experts to share the latest research in the field and to foster networking opportunities on BPAN disease research. \nBPAN disease is a rare genetic neurodegenerativ disorder associated to a beta propeller protein\, BPAN. It’s characterized by brain iron accumulation and belongs to the group of NBIA. As the gene mutation is on chromosome X\, the disease affects more females than males. \nVenue: BBS \n Registration until April 26th. \nDownload the program (pdf) \nMore details\nhttps://www.autourdubpan.fr/symposium2024/lang-en/ \n
URL:https://www.bordeaux-neurocampus.fr/event/3rd-bpan-disease-symposium-in-france/
CATEGORIES:A la une,Pour les scientifiques,Symposiums
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240517T113000
DTEND;TZID=Europe/Paris:20240517T113000
DTSTAMP:20260422T222014
CREATED:20220909T134050Z
LAST-MODIFIED:20240513T063824Z
UID:150784-1715945400-1715945400@www.bordeaux-neurocampus.fr
SUMMARY:Friday Seminar - Marilena Griguoli
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine \n\nMarilena Griguoli\n– Institute of Molecular Biology and Pathology of the National Research Council (CNR)\, Rome\n– European Brain Research Institute (EBRI)\, Rome \nInvited by Christophe Mulle \nTitle\n Role of septal cholinergic neurons in social novelty discrimination \nAbstract\nIn spite of its well-established neuromodulatory effect on attention\, memory and learning\, the role of acetylcholine (ACh) in social memory\, meaning the ability of an animal to discriminate between a stranger and a familiar one is less known. Medial Septum/Diagonal Band of Broca (MSDB) nuclei contain cholinergic neurons projecting to different brain areas including the hippocampal CA2 region\, involved in social memory encoding. Here\, different strategies have been used to control the activity of cholinergic neurons in the MSDB to evaluate its effect on social memory and on CA2 circuit functionality. Our results point to nicotinic ACh receptors as essential players in social memory by controlling inhibition in the CA2 region. Alterations in ChAT neurons have been observed in Autism Spectrum Disorders (ASD)\, neurodevelopmental conditions characterized by social isolation\, stereotyped movements and communication challenges. Some forms of ASD are associated with mutations in genes encoding for synaptic proteins including the neuroligin 3 (NLG3)\, a postsynaptic adhesion molecule that binds its presynaptic partner neurexin and stabilizes both excitatory and inhibitory synapses. Mice lacking NLG3 (NLG3-/y) show deficits in social interaction and social memory similar to those observed in autistic patients. Here\, we propose to study whether cholinergic dysfunction accounts for social memory deficits observed in NLG3-/y mice. Conditional suppression of Nlg3 expression in MSDB ChAT neurons induced an impairment in both social memory and synaptic function similarly to what observed in NLG3-/y mice. The rescue of Nlg3 expression in MSDB ChAT neurons of NLG3-/y mice will corroborate the evidence that a cholinergic dysfunction may cause social memory deficits in ASD. \nKey pubblications\nPizzarelli R\, Pimpinella P\, Jacobs C\, Tartacca A\, Kullolli U\, Monyer H\, Alberini C M\, Griguoli M (2023). Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3-/y mouse model of ASDs. Front Cell Neurosci\, 17:1332179. \nPimpinella D\, Mastrorilli V\, Giorgi C\, Coemans S\, Lecca S\, Lalive AL\, Ostermann H\, Fuchs EC\, Monyer H\, Mele A\, Cherubini E\, Griguoli M (2021). Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition. ELife 10:e65580 \nModi B\, Pimpinella D\, Pazienti A\, Zacchi P\, Cherubini E\, Griguoli M (2019). Possible implication of the CA2 hippocampal circuit in social cognition deficits observed in the neuroligin 3 knock-out mouse\, a non-syndromic animal model of Autism. Front Psychiatry 10: 513. \n  \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-marilena-griguoli/
CATEGORIES:A la une,Pour les scientifiques,Séminaire du vendredi
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