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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;VALUE=DATE:20201102
DTEND;VALUE=DATE:20201107
DTSTAMP:20260429T102608
CREATED:20201014T145747Z
LAST-MODIFIED:20201014T153737Z
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SUMMARY:Cajal online lecture series: Single Cell Transcriptomics
DESCRIPTION:Online Zoom Webinar  \nRegister by 1 November 2020 \n\n\n\nCourse overview\n\n\n\n\n\n\nTo be able to perform molecular analysis on the scale of single-cells with a throughput of 1000s of cells per experiment opens an unprecedented window into neuroscience and biology. We can now ask questions on how different cell types arise\, respond to stimuli or are changed in disorders. The multitude of data also moves molecular biology into a new era in terms of data analysis and statistics\, changing the demands on researchers. In this online course\, we will hear from some of the leaders in the field in the use of single-cell transcriptomics and the analysis of the nervous system. The aim is to cover a wide range of aspects from chemistries and methodologies of single cell transcriptomics to computational methods to leverage this new wealth of data to push our understanding of the brain. \n\n\n\n\n\n\n\n\nDirectors\n\n\n\n\n\n\n\n\n\n\n\n\n\nJens Hjerling-Leffler\nCo-Director\nKarolinska Institute\,  Sweden\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nPeter Kharchenko\nCo-Director\nHarvard Medical School\, USA\n\n\n\n\n\n\n\n\n\n\n\n\n\n  Directors info  \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nKeynote Speakers\n\nNaomi Habib – Edmond & Lily Safra Center for Brain Sciences (ELSC)\, Israel\nKenneth Harris – University College London (UCL)\, UK\nEd Lein – Allen Institute for Brain Science\, US\nSten Linnarsson – Karolinska Institute\, Sweden\nJohn Marioni – European Bioinformatics Institute (EMBL-EBI)\, UK\nAna Martin-Villalba – German Cancer Research Center (DKFZ)\, Germany\nSarah Teichmann – Wellcome Sanger institute\, UK\nKun Zhang – Department of Bioengineering\, University of California\, US\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nGeneral information\n\n\n\n\n\nEach session is composed of a 45 min. lecture followed by a 15 min. Q&A. \nQuestions can be asked through typing them in the Zoom Q&A system. \nParticipation is free of charge. Registration is compulsory to get the access link to the Zoom Webinar. \n\nMore details\nhttp://cajal-training.org/2020/single-cell-transcriptomics/ \n\n\n\n\nOnline lecture series \nwith the support of the Bordeaux School of Neuroscience \n\n\n\n\n\n\nThe online lecture series will be hosted by the Cajal Administration in partnership with the Bordeaux School of Neuroscience. \nFor additional information on this online lecture series\, please email the Cajal Programme administration at info@cajal-training.org. \n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/cajal-online-lecture-series-single-cell-transcriptomics/
CATEGORIES:A la une,Cajal Lectures,Formations,Pour les scientifiques
ATTACH;FMTTYPE=image/jpeg:https://www.bordeaux-neurocampus.fr/wp-content/uploads/2020/05/cajal-novembre2020.jpg
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DTSTART;TZID=Europe/Paris:20201106T113000
DTEND;TZID=Europe/Paris:20201106T123000
DTSTAMP:20260429T102608
CREATED:20200706T175253Z
LAST-MODIFIED:20201022T082135Z
UID:123019-1604662200-1604665800@www.bordeaux-neurocampus.fr
SUMMARY:Conférence mensuelle (PhD seminar series) - Aline Desmedt
DESCRIPTION:Séminaire en ligne.\n \nL’adresse pour la visioconférence sera diffusé par email environ une semaine avant. \n\nAline Desmedt\nTeam « Pathophysiology of declarative memory »\nNeurocentre Magendie \nThe hippocampus at the core of PTSD-like memory\nPost-traumatic stress disorder (PTSD) is characterized by a paradoxical memory alteration with hypermnesia for salient traumatic cues and amnesia for the traumatic context. Clinical studies strongly suggest that a deficit in trauma contextualization would leave traumatic memory out of control and thus prone to be automatically reactivated upon trauma-related cues in any context through flashbacks. In this view\, recovery from PTSD-related hypermnesia would thus depend on recovery from contextual amnesia. Yet\, preclinical research focuses exclusively on the emotional hypermnesia\, leaving unexplored the putative causal role of a deficit in the hippocampus-dependent trauma contextualization in PTSD. \nUsing the first animal model that precisely recapitulates PTSD-related hypermnesia and amnesia\, we first show that compared to normal fear memory\, PTSD-like fear memory is specifically associated with hippocampal hypoactivation and neuronal alterations. Second\, we show that optogenetic inhibition of the hippocampus (dCA1) during stress can produce PTSD-like memory in mice\, whereas activating the dCA1 prevents its formation and promotes normal contextual fear memory. Finally\, trauma re-contextualization normalizes PTSD-like memory\, promoting the expression of a long-lasting normal fear memory. \nThese findings indicate that PTSD-like memory depends on contextual amnesia and that promoting the hippocampal function promotes a switch from PTSD-like to normal fear memory via trauma contextualization. Therefore\, these data call for promoting therapeutic approaches of PTSD centered on trauma contextualization and its underlying hippocampal mechanisms. \n
URL:https://www.bordeaux-neurocampus.fr/event/conference-mensuelle-phd-seminar-novembre2020/
CATEGORIES:A la une,Conférences mensuelles,Pour les scientifiques
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