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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;VALUE=DATE:20191015
DTEND;VALUE=DATE:20191031
DTSTAMP:20260421T103132
CREATED:20190208T093944Z
LAST-MODIFIED:20240131T160210Z
UID:103139-1571097600-1572479999@www.bordeaux-neurocampus.fr
SUMMARY:Cajal course : Advanced Techniques for Synapse Biology - Lectures
DESCRIPTION:October 15 – 9:00\nInna SLUTSKY\nPlasticity-stability balance in hippocampal circuits: From basic principles to malfunctions \nOctober 17 – 9:00\nMonica DI LUCA\nSynapses dynamic in health and diseases \nOctober 18 – 9:00\nDaniel CHOQUET\nNanoscale imaging of synapse organization and function \nOctober 24 – 9:00\nDietmar SCHMUCKER\nMolecular Mechanisms of Neurite branching and CNS Synaptogenesis \nOctober 25 – 9:00\nBart DE STROOPER\nFrom biochemical to cellular phase in Alzheimer’s disease \nOctober 26 – 9:00\nReinhard JAHN\nSynaptic vesicles – key organelles in synaptic transmission \nOctober 28 – 9:00\nClaudia BAGNI\nBrain connectivity and molecular pathways in autism \nOctober 29 – 9:00 \nMatthijs VERHAGE\nUnique and shared principles in the secretion of different chemical signals from mammalian CNS neurons \nOctober 30 – 9:00\nStéphane OLIET\nContribution of astrocytes to synaptic transmission and plasticity \nAbout the course\nSynaptic contacts are critical for information transfer in the brain. They are specialized sites\, often far from the neuronal cell body\, and operate in part as independent units.  Synaptic contacts are very diverse and synaptic plasticity underlies memory formation and thought. Synaptic dysfunction is strongly associated with diseases of the brain and this is thought to be an early feature of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. The study of the molecular mechanisms of synaptic function and plasticity are the key to understanding how the brain works and what goes wrong in disease. Many of these processes are evolutionarily very well conserved and researchers study synaptic processes in a variety of species and in human neuron models.  The training of a new generation of neuroscientists with advanced techniques is crucial to make these studies a success in the coming decades. \nThe advanced course will allow students to integrate the basic techniques in molecular and cellular neurobiology with advanced state-of-the art molecular\, imaging and functional methodologies\, through direct hands-on experiments using a variety of models. \nCourse director\n \nPatrik Verstreken\nVIB-KULeuven\nBelgium \n  \n  \nCo-Directors \n \nNathalie Sans\nINSERM U8\nUniversity of Bordeaux\nFrance \n  \n  \n \nLaurent Groc\nCNRS – IINS\nUniversity of Bordeaux\nFrance \n  \n  \n\nThis course is organised in partnership with ERA-NET NEURON. \n \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/event/cajal-advanced-techniques-for-synapse-biology/
CATEGORIES:A la une,Cajal Lectures,Pour les scientifiques
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DTSTART;TZID=Europe/Paris:20191022T140000
DTEND;TZID=Europe/Paris:20191022T150000
DTSTAMP:20260421T103132
CREATED:20191017T120203Z
LAST-MODIFIED:20191017T120203Z
UID:112164-1571752800-1571756400@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire CBiB : Guillaume Bernard
DESCRIPTION:Séminaire de Bioinformatique et Biologie Computationnelle sur la thématique d’analyse de données métagénomiques. \nL’exposé sera suivi d’une pause café. \nOrateur : Guillaume Bernard (Sorbonne Université\, MNHN\, Paris) \nTITRE : Next-generation phylogenomics: alignment-free approaches\, sequence similarity networks and more \nLieu : CGFB – salle de conférences \nRésumé : \nFrom the 2000’s with the development of Next Generation Sequencing (NGS)\, biologists have been able to sequence microbes directly from the environment. The ‘microbial dark matter’ represented in metagenomes could contain a huge amount of new information about Earth’s microbial diversity and the origins of life\, as well as solutions to medical problems or the adaptation to climate changes. NGS brought a deluge of collected sequence data in which we found a huge diversity and uncharacterized organisms that weren’t cultivated in the laboratory. Alternative approaches to the classical phylogenetic methods based on multiple sequence alignment (MSA)\, such as sequence similarity networks (SSN) and alignment-free (AF) methods\, have been increasingly used in evolutionary analyses to cope with the increasingly large amount of data. These latter approaches are faster and more scalable than their MSA-based counterpart\, and can be applied to a broader range of data (sequencing reads\, whole genomes\, etc). I will start with a brief introduction to the AF approaches followed by an overview of the different methods available. Next\, I will show the network-based methods and their applications. Finally\, I will present a novel approach combining the SSN and the AF methods to quickly identify gene/proteins of interest in metagenomic data and infer proxies of phylogenies\, robust to long branch attraction\, when the data are too large or divergent to perform a MSA. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-cbib-guillaume-bernard/
CATEGORIES:A la une,Hors Bordeaux Neurocampus
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