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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20190909T090000
DTEND;TZID=Europe/Paris:20190926T130000
DTSTAMP:20260604T080045
CREATED:20190208T093515Z
LAST-MODIFIED:20190925T160043Z
UID:103126-1568019600-1569502800@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures : Whole brain imaging
DESCRIPTION:Lecture program\nFree access / Venue: CGFB \nAu CGFB\, entrée libre \n\nWednesday\, September 11th – 9:00\nJean-Michel FRANCONI\nMR image formation \nThursday\, September 12th – 9:00\nRuss POLDRACK\nTask-related fMRI \nFriday\, September 13th – 9:00\nTim DYRBY\nWhite matter architecture \nMonday\, September 16th – 9:00\nFabrice CRIVELLO\nStructural brain MRI \nWednesday\, September 18th – 9:00\nUrs RIBARY\nEEG-MEG connectivity dynamics \nWednesday\, September 18th – 11:00\nMickaël TANTER\nFunctional ultrasound \nThursday\, September 19th – 9:00\nArno VILLRINGER\nInfrared imaging \nMonday\, September 23rd – 9:00\nGitte KNUDSEN\nNeuroPET \nTuesday\, September 24th – 9:00\nSven CICHON\nNeuroimaging and omics \nTuesday\, September 24th – 11:45\nChristophe TZOURIO\nImaging markers for neuro-epidemiology \nWednesday September 25th – 9:00\nRoundtable :\nKatrin AMUNTS\, Gwenaëlle DOUAUD & Arthur TOGA\nDatabasing\, sharing and meta-analysing \nThursday\, September 26th – 9:00\nLaura HARSAN\nPreclinical imaging \nThursday\, September 26th – 11:00\nRoundtable :\nStéphanie DEBETTE & Kathinka EVERS\nBrain imaging ethics \n  \n  \nAbout the course\nThe CAJAL course in Whole Brain Imaging is an intensive three-week course that will carry participants through the theory and practice of advanced methods for investigating brain structure-function relationships at the organ level. The course will balance lectures from world-acknowledged neuroimaging experts to experimental demonstrations and hands-on laboratory work in small groups. Participants will be introduced to a wide spectrum of techniques\, from microscopic post-mortem brain cyto- and myelo-architectony to macroscopic in vivo 3D-imaging using magnetic resonance\, functional ultrasound\, near-infrared spectroscopy\, electromagnetic waves\, and gamma-ray emission tomography. Issues associated with whole brain neuroimaging multimodality and data-sharing will also be addressed. During the course\, each participant will be given the opportunity to acquire and analyze whole-brain neuroimaging data in both preclinical and clinical environments. \nCourse director \nKatrin Amunts\nJülich Research Centre\nGermany \n  \n  \nCo-directors \nBernard Mazoyer\nCNRS\nNeurodegeneratives Diseases Institute\nUMR 5293\nUniversity of Bordeaux\nFrance \n  \nSylvain Miraux\nCNRS – RMSB\nUMR 5536\nUniversity of Bordeaux\nFrance \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/event/cajal-whole-brain-imaging/
CATEGORIES:Formations
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DTSTART;TZID=Europe/Paris:20190913T140000
DTEND;TZID=Europe/Paris:20190913T170000
DTSTAMP:20260604T080045
CREATED:20190912T181936Z
LAST-MODIFIED:20190912T184206Z
UID:110997-1568383200-1568394000@www.bordeaux-neurocampus.fr
SUMMARY:Soutenance de thèse - Rafael de Sa
DESCRIPTION:Location: CGFB \nSupervisor: Andreas FRICK \nTitle: The role of intrinsic neuronal excitability for Prelimbic network function \nSummary\nThe goal of this work was a characterization of the cellular identity of Layer 5 neurons of the prelimbic (PL) subarea of the medial prefrontal cortex (mPFC) in mice. In performing this analysis\, we considered the intrinsic properties of these neurons\, their morphology\, connectivity and finally their transcriptional profile. \nIn the first part of this study\, we considered the question of how the expression of the receptors a of important neuromodulatory molecule (dopamine) can be used\, in addition to other criteria\, for the characterization of cell-type identity. In the PL\, two major receptor types\, Dopamine 1 (D1R) and 2 (D2R) receptor have been described. We characterized the cellular identity of these neurons in wild-type (WT) mice and then used these findings as a reference for the characterization of molecular and cellular defects in the PL of Fmr1KO\, a model for fragile X syndrome (FXS) and autism spectrum disorder (ASD). \nTo do this\, we analyzed the intrinsic electrical properties of these neurons and performed a clustering of neurons based on these intrinsic properties. We analyzed the morphology of these neurons\, as well as their principal projections to other brain areas. In addition\, RNA sequencing analysis revealed more than 500 genes differently expressed between D1R and D2R neurons. Further analysis of the transcriptional profile of these neurons revealed differences based on a number of different categories such as the expression of ion channels\, transcription factors and cell adhesion molecules. This data then served as a reference for the characterization of molecular and physiological changes in the PL in FXS/ASD. FXS is the most common inherited cause of intellectual disability and the most frequent genetic cause of autism. FXS is characterized by learning and memory deficits\, repetitive behavior\, seizures and hypersensitivity to sensory (e.g. visual) stimuli. Dopamine modulation is altered in this model and it was thus pertinent to determine how changes to this important modulatory system might impact on cell identity in FXS. We observed differences in intrinsic properties between D1R and D2R neurons. However\, these changes showed important differences from those observed in WT mice. These differences might be explained by alterations in mRNA expression in these two neuronal populations in Fmr1KO mice. In particular\, our findings point to an overexpression of genes particularly in D1R population of Fmr1KO mice. \nIn the second part of this study\, we turned our attention to changes in the intrinsic electrophysiological properties of amygdala-projecting PL during early encoding of contextual fear memories. We used contextual fear conditioning together with retrograde tracing and whole-cell electrophysiological recordings of labeled pyramidal neurons in adult 2-3 month old male C56BL/6J mice. We show that neurons projecting to the amygdala display learning-dependent changes in neuronal excitability during early encoding of contextual fear conditioning\, but not at a remote time-point. In addition\, we demonstrated that manipulation of the intrinsic properties of this specific population during the early phases or memory encoding (but not during remote phases) lead to alterations in fear memory recall at a remote time-point. \n  \nKeywords : Prefrontal cortex\, Dopamine\, Ion channels\, Fragile X syndrome\, Memory \n  \nJury members:\nDr. Pietropaolo\, Susanna  – Bordeaux\, FRANCE \nProf. Ramaswami\, Mani – Dublin\, IRELAND Rapporteur \nDr. Coutureau\, Etienne – Bordeaux\, FRANCE \nDr. Schubert\, Dirk – Nijmegen\, NETHERLANDS \n
URL:https://www.bordeaux-neurocampus.fr/event/soutenance-de-these-rafael-de-sa/
CATEGORIES:Thèses
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