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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190121
DTEND;VALUE=DATE:20190203
DTSTAMP:20260505T004848
CREATED:20190124T112412Z
LAST-MODIFIED:20190126T121704Z
UID:102243-1548028800-1549151999@www.bordeaux-neurocampus.fr
SUMMARY:SyDAD : Advanced Methods for Preclinical Alzheimer Research
DESCRIPTION:ITN Marie Sklodowska Curie\, financé par l’EU. \n\nDu 21 janvier 2019 au 2 février 2019 \n\nFor more information: http://www.sydad.eu/ad-methodology-workshop \nCourse organizers:\nChristophe Mulle\, Susanne Frykman\,  Bengt Winblad\,\nUniversity of Bordeaux\,  Karolinska Institut et Karolinska Institutet \nContact: Susanne.frykman@ki.se \nListe des intervenants\nLieu : CGFB – Salle de conférence \nLundi 21 janvier \n11h00: Bengt Winblad – What has happened in the last 5 years regarding treatment of AD? \nMardi 22 janvier \n9h00: Bart de Strooper – The cellular phase of Alzheimer’s Disease: integration of the amyloid and inflammation hypothesis \n11h00: Agneta Nordberg – Interactive pathological processes in Alzheimer´s disease and other proteinonpathies as studied by PET imaging \nMercredi 23 janvier\n \n9h00: Jean-Francois Dartigues – Alzheimer in the city \n11h00: Florence Pasquier – Early and late onset Alzheimer’s disease \nLundi 28 janvier\n \n9h00: Eckhard Mandelkow – Structure\, aggregation\, and interaction partners \nEva Mandelkow –  Animal models\, modes of toxicity\, and therapeutic approaches \n11h00: Michael Heneka – Innate immune activation in Alzheimer’s disease \nMardi 29 janvier\n \n9h00: Monica Di Luca – Amyloid in the synapse: an inner dialogue in the frame of Alzheimer Disease \n11h00: John Hardy – Genomic analysis of neurodegenerative disease \nMercredi 30 janvier\n \n11h00: Petr. Novak – To be determined \n  \n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/sydad-advanced-methods-for-preclinical-alzheimer-research/
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20190125
DTEND;VALUE=DATE:20190126
DTSTAMP:20260505T004848
CREATED:20181130T101146Z
LAST-MODIFIED:20190129T170238Z
UID:100794-1548374400-1548460799@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire inaugural du BIC électronique
DESCRIPTION:Centre Broca Nouvelle-Aquitaine et au Centre de génomique fonctionnelle de Bordeaux \n \nhttp://www.bic.u-bordeaux.fr/symposium-pie/ \n
URL:https://www.bordeaux-neurocampus.fr/event/les-nouvelles-approches-de-pointe-en-microscopie-electronique/
CATEGORIES:Symposiums
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DTSTART;TZID=Europe/Paris:20190125T113000
DTEND;TZID=Europe/Paris:20190125T123000
DTSTAMP:20260505T004848
CREATED:20190103T174330Z
LAST-MODIFIED:20200121T113947Z
UID:101342-1548415800-1548419400@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire - Eric Hanse
DESCRIPTION:Erik Hanse\nEric Hanse\nPrincipal Investigator: Cellular Neurophysiology / Department of Physiology at Institute of Neuroscience and Physiology / Goteborg University \nInvitant : Laurent Groc\nTeam leader / Development and Adaptation of Neuronal Circuits / IINS \n\nAbstract :\nThe cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space and\, together with the interstitial fluid (ISF)\, forms a continuous fluidic network that bathes all cells of the central nervous system. As such\, the CSF is well positioned to actively distribute neuromodulators to neural circuits in vivo via volume transmission.\nWe have recently shown here that replacing artificial CSF (aCSF)\, routinely used for perfusion of brain slices in vitro\, with human CSF (hCSF) powerfully boosts spontaneous firing of CA1\, CA3\, layer 5 pyramidal neurons as well as of fast spiking- and non-fast spiking interneurons in the rat brain slice. In these experiments\, the aCSF was matched to the hCSF with respect to electrolyte and glucose composition. CA1 pyramidal neurons in hCSF display lowered firing thresholds\, more depolarized resting membrane potentials and reduced input resistance\, mimicking properties of pyramidal neurons recorded in vivo.\nThe increased excitability of CA1 pyramidal neurons was completely occluded by intracellular application of GTPγS\, suggesting that endogenous neuromodulators in hCSF act on G-protein coupled receptors to enhance excitability.\nMoreover\, replacing aCSF with hCSF induced spontaneous gamma activity in the hippocampal slice that was reversed by washout. Our findings highlight a previously unknown function of the CSF in promoting spontaneous neuronal activity\, and may help to explain differences observed in vivo and in vitro. \n\nSelected publications\nBjörefeldt\, Andreasson\, Daborg\, Riebe\, Wasling\, Zetterberg and Hanse (2015) Human cerebrospinal fluid increases the excitability of pyramidal neurons in the in vitro brain slice J Physiol 593:231-241 \n Björefeldt\, Wasling\, Zetterberg and Hanse (2016) Neuromodulation of fast-spiking and non-fast-spiking hippocampal CA1 interneurons by human cerebrospinal fluid J Physiol 594:937-952 \n Björefeldt\, Roshan\, Forsberg\, Zetterberg\, Hanse and Fisahn (2019) Human cerebrospinal fluid promotes spontaneous gamma oscillations in the hippocampus in vitro Submitted \n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-eric-hanse/
LOCATION:Centre Broca Nouvelle-Aquitaine\, 38 Rue Albert Marquet\, Bordeaux\, 33000\, France
CATEGORIES:A la une,Séminaire du vendredi
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