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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;TZID=Europe/Paris:20181214T110000
DTEND;TZID=Europe/Paris:20181214T110000
DTSTAMP:20260505T021151
CREATED:20180730T163928Z
LAST-MODIFIED:20190117T101529Z
UID:97469-1544785200-1544785200@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire - Marina Martinez
DESCRIPTION:Récupération de la marche après des lésions de la moelle épinière\, une histoire de cortex. \n\nMarina Martinez\nProfesseure\, adjointe Département de Neurosciences Faculté de Médecine Université de Montréal \nInvitant :\nGrégory Barrière\,\nPhD\, CRCN CNRS\,\nLaboratoire INCIA Université de Bordeaux (CNRS UMR 5287) \n\nAbstract :\n250 000 nouveaux cas de lésions de la moelle épinière surviennent chaque année dans le monde. Dans la majorité des cas\, les patients ont une lésion incomplète qui épargne des connexions entre le cerveau\, qui initie les mouvements\, et les circuits moteurs de la moelle épinière\, qui les génèrent. Ces blessés médullaires peuvent éventuellement récupérer certaines fonctions motrices avec le temps\, mais la récupération demeure souvent partielle. Un de mes objectifs de recherche est de comprendre comment certaines structures du cerveau\, et en particulier le cortex moteur\, interagissent avec les circuits moteurs de la moelle épinière pour optimiser la récupération de la marche après des atteintes médullaires. Pour ce faire\, nous nous appuyons sur des paradigmes innovants permettant de manipuler l’activité corticale chez le rat que nous combinons à des approches comportementales et des techniques électrophysiologiques et neuroanatomiques. Nous exploitons également ces mécanismes pour faciliter la récupération de la marche en testant des interfaces cerveau-machine. Ces recherches ont un intérêt clinique et thérapeutique important dans la mesure où le cortex moteur est une structure cérébrale pouvant être facilement ciblée chez l’humain. \n  \nLocomotor recovery following spinal cord injury\, a tale of cortex\nMarina Martinez\, Department of Neuroscience\, Faculty of Medicine\, Université de Montréal (QC\, Canada) ; Groupe de Recherche sur le Système Nerveux Central ; Centre de Recherche de l’Hôpital du Sacré-Cœur de Montréal.\nHost : G. Barrière\, CRCN CNRS\, Université de Bordeaux\, INCIA (CNRS UMR 5287) \nWith a worldwide prevalence of about 250\,000 new cases each year\, spinal cord injuries (SCI) are a major cause of disability. For SCI individuals\, limitations in sensory-motor activities such as walking and posture severely affect their quality of life. In most cases\, patients have an incomplete injury that spares some connections between the brain\, which initiates movements\, and the spinal circuits\, which generate them. These patients can eventually recover some motor functions with time but that recovery is often incomplete. One of the most promising avenues is to take advantage of the remaining communication pathways between the brain and the spinal cord and that could potentially be activated in order to restore function. One of my research interest is to study how brain structures with partial connectivity to the spinal cord\, and particularly the motor cortex\, facilitate recovery of walking after SCI. We combined cutting edge paradigms allowing to manipulate cortical activity with behavioral\, electrophysiological and neuroanatomical techniques. We also deploy innovative brain-machine interfaces for motor control in animal models. Our experiments have important clinical implications in humans in whom the motor cortex can be easily targeted by activity-based neurorehabilitation and brain stimulation protocols. \n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-don-wilson/
LOCATION:INCIA\, Campus Carreire - bât. 2A - 2ème étage\, France
CATEGORIES:Séminaire du vendredi
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DTSTART;TZID=Europe/Paris:20181214T133000
DTEND;TZID=Europe/Paris:20181214T133000
DTSTAMP:20260505T021151
CREATED:20181205T175854Z
LAST-MODIFIED:20200102T152423Z
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SUMMARY:Soutenance de thèse - Geoffrey Terral
DESCRIPTION:\n\n\n\n\nGeoffrey Terral\nDate de la soutenance : 14/12/2018 – 13h30.\nLieu : Neurocentre Magendie Seminar room. \nDirecteur de thèse Dr Giovanni MARSICANO\, Université de Bordeaux\, team leader: « Endocannabinoids and Neuroadaptation » \n Being involved in many behavioral functions\, olfaction has powerful influence in guiding our actions. Odors communicate with the central nervous system via specialized receptors in the nose olfactory epithelium that generate neuronal signals\, which in turn are eventually distributed and processed in many brain regions. In particular\, the anterior piriform cortex (aPC) is an important olfactory area involved in perception and integration of odors.\nGiven the extended role of the main cannabinoid type-1 (CB1) receptor in sensory and memory brain functions\, we hypothesized that CB1 receptors could modulate odor processing in the aPC. To this aim\, using a combination of anatomical\, electrophysiological\, and pharmacological approaches\, we first characterized the distribution of CB1 receptors and their ability to regulate aPC circuits. We found that CB1 receptors are mainly expressed in GABAergic interneurons where their activation regulates inhibitory transmission and plasticity.\nThen\, we evaluated the role and the impact of CB1 receptor modulation on odor-related aPC processing. In vivo calcium imaging revealed that odor-evoked aPC activity is affected by alteration of CB1 receptor signaling. Additionally\, we demonstrated that physiological aPC-CB1 receptors functioning is necessary for retrieve appetitive but not aversive olfactory memory\, likely through modulation of local inhibitory circuits. Overall\, this work contribute to a better understanding of how CB1 receptors modulate olfactory processes in the aPC. \nPublications \nLayer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus. 2016 Jun 27;6:28454. Scientific Reports. Michelangelo Colavita\, Geoffrey Terral\, Clement E. Lemercier\, Filippo Drago\, Giovanni Marsicano♯\, Federico Massa♯ \nA Cannabinoid Link Between Mitochondria and Memory. 2016 Nov 9;539(7630):555-559. Nature.\nEtienne Hebert-Chatelain♯\, Tifany Desprez♯\, Roman Serrat♯\, Luigi Bellocchio♯\, Edgar Soria-Gomez\, Arnau Busquets-Garcia\, Antonio Christian Pagano Zottola\, Anna Delamarre\, Astrid Cannich\, Peggy Vincent\, Marjorie Varilh\, Laurie M. Robin\, Geoffrey Terral\, M. Dolores García-Fernández\, Michelangelo Colavita\, Wilfrid Mazier\, Filippo Drago\, Nagore Puente\, Leire Reguero\, Izaskun Elezgarai\, Jean-William Dupuy\, Daniela Cota\, Maria-Luz Lopez-Rodriguez\, Gabriel Barreda-Gómez\, Federico Massa\, Pedro Grandes\, Giovanni Benard♯\, Giovanni Marsicano♯ \nHippocampal CB1 receptors control incidental associations. 2018 Sep 19;99(6):1247-1259. Neuron. Arnau Busquets-Garcia\, Jose Fernando Oliveira da Cruz#\, Geoffrey Terral#\, Antonio Christian Pagano Zottola#\, Edgar Soria-Gomez\, Andrea Contini\, Hugo Martin\, Bastien Redon\, Marjorie Varilh\, Christina Ioannidou\, Filippo Drago\, Federico Massa\, Xavier Fioramonti\, Pierre Trifilieff\, Guillaume Ferreira#\, Giovanni Marsicano# \nCB1 receptors in the anterior piriform cortex control odor preference memory. Submitted\nGeoffrey Terral\, Arnau Busquets-Garcia\, Marjorie Varilh\, Svein Achicallende\, Astrid Cannich\, Luigi Bellocchio\, Federico Massa\, Nagore Puente\, Edgar Soria-Gomez\, Pedro Grandes\, Guillaume Ferreira# & Giovanni Marsicano#. \nCB1 receptors dynamically control olfactory processes in the anterior Piriform Cortex. In preparation. Geoffrey Terral\, Gabriel Lepousez\, Marjorie Varilh\, Arnau Busquets-Garcia\, Astrid Cannich\, Antoine Nissant\, Federico Massa\, Edgar Soria-Gomez\, Pierre-Marie Lledo\, Guillaume Ferreira# & Giovanni Marsicano#. \n\n\n\n\n\n\n\n\n\n\nJury\n\nDr OLIET Stéphane\nUniversité de Bordeaux\, \nFrance\, Président \nPr WILSON Donald\, \nNYU School of Medicine\, \nEtats-Unis\, \nRapporteur \nDr BACCI Alberto\nICM\, France\, \nRapporteur \nDr ROUX Lisa\, \nUniversité de Bordeaux\, \nFrance\, \nExaminatrice\nDr FERREIRA Guillaume\, \nUniversité de Bordeaux\, \nFrance\, \nInvité \nDr MARSICANO\, Giovanni\, \nUniversité de Bordeaux\, \nFrance\, \nDirecteur de thèse \n\n\n\n\n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/these-geoffrey-terral/
CATEGORIES:Thèses
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