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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;TZID=Europe/Paris:20180713T113000
DTEND;TZID=Europe/Paris:20180713T113000
DTSTAMP:20260505T110728
CREATED:20180607T152631Z
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UID:56834-1531481400-1531481400@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire Yasunori Hayashi
DESCRIPTION:13 juillet 2018 à 11h00 (Amphi Broca Nouvelle-Aquitaine / Campus Carreire) \nYasunori Hayashi\nPhD\, Department of Pharmacology\nKyoto University Graduate School of Medicine \nInvitant : Daniel Choquet\nDirecteur de L’IINS \nAbstract :\nLong-term synaptic plasticity requires a mechanism that converts short Ca2+ pulses into persistent biochemical signaling to support the changes in the function and structure of synapses over long period of time. Here\, we present a positive feedback loop\, formed by a « reciprocally activating kinase-effector complex » (RAKEC) in dendritic spines\, enabling the persistence and confinement of the molecular memory. We found that stimulation of a single spine causes the rapid formation of a RAKEC consists of a kinase CaMKII and its substrate a RacGEF TIAM1\, which can stably promote actin-polymerization through Rac1\, thereby maintaining the structure of the spine over a long period of time during LTP. This is achieved by a pseudo-autoinhibitory domain found within TIAM1\, homologous to the autoinhibitory domain of CaMKII. RAKEC can store biochemical information in small subcellular compartments\, thus potentially serving as a general mechanism for the production of prolonged and compartmentalized signaling. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-yasunori-hayashi-2/
CATEGORIES:Séminaire du vendredi
ATTACH;FMTTYPE=image/jpeg:https://www.bordeaux-neurocampus.fr/wp-content/uploads/2018/06/Hayashi280p.jpg
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