BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240619T140000
DTEND;TZID=Europe/Paris:20240619T140000
DTSTAMP:20260421T102823
CREATED:20240430T170215Z
LAST-MODIFIED:20240430T170927Z
UID:171253-1718805600-1718805600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Maxime Cazorla
DESCRIPTION:Venue: Centre Broca \n\nMaxime Cazorla\nInstitut de Neuroscience de la Timone / INT Neurotechnology Center\nAix Marseille Université\nteam / ntc / twitter \nInvited by Clémentine Bosch Bouju (NutriNeuro) \nTitle\nStudying axon plasticity : from intracellular dynamics to large-scale rewiring \nAbstract\nLong regarded as a rigid and aging organ\, the adult brain is capable of profound reorganization at the macroscopic level of its cerebral circuits. This emerging concept\, known as ‘brain rewiring’\, postulates that neural circuits keep restructuring in response to neuronal activity. But what makes axonal rewiring efficient in the adult brain? How is it regulated with experience and learning? Alterations in brain connectivity exist in neurodegenerative diseases\, such as Huntington’s disease and Amyotrophic Lateral Sclerosis. Could we reverse engineer the rewiring capacity of the brain to restore dysfunctional networks on-demand? In the lab\, we address these burning questions by investigating the molecular and cellular underpinnings of axonal remodeling\, using an organ-on-a-chip approach\, in health and disease. \nIn this talk\, I will present how brain-on-chip microdevices helped us to discover unexpected intracellular mechanisms regulating axonal remodeling. I will also introduce our latest human-based models and technological development to improve biomedical research. Finally\, I will briefly talk about RAIL\, a photoinducible technology targeting axon remodeling programs to connect and disconnect neural networks on-demand. \nKey publications\nCazorla M\, de Carvalho FD\, Chohan MO\, Shegda M\, Chuhma N\, Rayport S\, Ahmari SE\, Moore H and Kellendonk C. (2014) Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry. Neuron. 2014 Jan 8;81(1):153-64. \nVirlogeux A\, Moutaux E\, Christaller W\, Genoux A\, Bruyère J\, Fino E\, Charlot B\, Cazorla M and Saudou F. (2018) Reconstituting Corticostriatal Network on‐a‐Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease. Cell Reports. 2018 Jan 2;22(1):110‐122 \nMoutaux E\, Christaller W\, Scaramuzzino C\, Genoux A\, Charlot B\, Cazorla M* and Saudou F*. (2018) Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons. Scientific Reports. 2018 Sep 7;8(1):13429. \nMoutaux E\, Charlot B\, Genoux A\, Saudou F and Cazorla M. (2018) An integrated microfluidic/microelectrode array for the study of activity‐dependent intracellular dynamics in neuronal networks. Lab Chip. 2018 Nov 6;18(22):3425‐3435 \nPoinsot M\, Maurin J\, Cesar W and Cazorla M. (2023) Liquid distribution system for a fluidic chip. Eur. Patent.EP/2023/03848 \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-maxime-cazorla/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
END:VEVENT
END:VCALENDAR