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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20230622T110000
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DTSTAMP:20260305T135135
CREATED:20230512T081011Z
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UID:159391-1687431600-1687431600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Lilly Bentall
DESCRIPTION:Venue : Centre Broca Nouvelle-Aquitaine \n\nLily M. Bentall\nLily M. Bentall\nDepartment of Anatomy\, School of Biomedical Sciences\nUniversity of Otago\, Dunedin\, New Zealand \nInvited by Clémentine Bosch Bouju (NutriNeuro) \nTitle\nChanges in SNpr activity underlying dyskinesia in Parkinsonian model rats \nAbstract\nMost (50-80%) Parkinson’s disease patients develop levodopa-induced dyskinesia (LID) within ten years of starting treatment. Once LID begins\, limited treatments are available to reduce this side effect. We hypothesise irreversible changes occur within the cortico-basal ganglia-thalamo-cortical network as subsequent levodopa administration always produces dyskinesia. \nWe recorded GABAergic substantia nigra pars reticulata (SNpr) neuronal activity under urethane anaesthesia from dyskinetic (LID+)\, non-dyskinetic (LID-\, lesioned rats dosed with levodopa but did not express LID)\, levodopa naïve PD-model (PD) and sham-lesioned (control\, administered levodopa) rats. Firing rate\, burstiness characteristics and LFP waveform features significantly changed between groups\, related specifically to dyskinesia expression. \nSNpr activity is altered by chronic levodopa administration. These changes hint that strengthened synaptic connections within the basal ganglia-thalamo-cortical network underlie dyskinesia expression. These findings could be important clinically to identify novel treatments that may reduce debilitating levodopa drug-induced side effects. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-lilly-bentall/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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