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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20241011T113000
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SUMMARY:Friday Seminar - Cheng-Chang "Maxo" Chen
DESCRIPTION:Venue : Centre Broca Nouvelle-Aquitaine \n \n\nDr. Cheng-Chang « Maxo » Chen \nDepartment of Clinical Laboratory Sciences and Medical Biotechnology\nCollege of Medicine\, National Taiwan University\, Taipei\, Taiwan \nInvited by Eric Boue-Grabot (IMN) \nTitle\nExploring Endolysosomal Ion Channels: Significance and Methodologies \nAbstract\nEndolysosomal ion channels\, such as TRPML2 and TPC2\, are essential regulators of intracellular trafficking\, calcium signaling\, and immune responses. This presentation highlights the importance of these channels and focuses on the use of theendolysosomal patch-clamp technique\, a highly specialized method for investigating ion channel activity within endolysosomal membranes. Through this approach\, we gain precise insights into the mechanisms by which these ion channels regulate various cellular processes\, including vesicular trafficking and pathogen defense. The endolysosomal patch-clamp technique has proven invaluable in studying the roles of multiple ion channels\, offering significant implications for understanding their contributions to human diseases\, including innate immunity and neurodegenerative diseases. This presentation will underscore how this methodology advances the exploration of ion channel function and informs potential therapeutic strategies for a range of diseases.\nReference\n\nGibbs KD\, et al. « Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation. » Cell Genom.\, 2023.\nChen CC\, et al. « TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles. » Sci Adv.\, 2020.\nSpix B\, et al. « Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. » Nat Commun.\, 2022.\nChen CC\, et al. « Patch-clamp techniques to study ion channels in lysosomes. » Nat Protoc.\, 2017.\n\n
URL:https://www.bordeaux-neurocampus.fr/event/seminar-cheng-chang-maxo-chen/
CATEGORIES:A la une,Pour les scientifiques,Séminaire du vendredi
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