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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20190208T113000
DTEND;TZID=Europe/Paris:20190208T130000
DTSTAMP:20260526T033818
CREATED:20190102T172651Z
LAST-MODIFIED:20190204T174530Z
UID:101219-1549625400-1549630800@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire - Sandrine Humbert
DESCRIPTION:Sandrine Humbert\nLieu CGFB \nSandrine Humbert\nDR INSERM\, team leader: Équipe « Progéniteurs neuraux et pathologies cérébrales » Grenoble Institut des Neurosciences – INSERM U836 – UGA \nInvitants : Maurice Garret de l’INCIA et Nathalie Sans du Neurocentre Magendie \n\nAbstract :\nHuntington Disease (HD) belongs to the family of late onset manifesting neurological disorders including Alzheimer and Parkinson diseases. The cause of HD is the presence of an abnormal expansion of a polyglutamine tract in the huntingtin (HTT) protein. HD is characterized by a long premanifest phase before onset of progressive neurological and psychiatric symptoms at adult age\, yet mutant HTT (mHTT) is expressed from the very beginning of life. Anyway\, given the adult onset and dysfunction and death of adult neurons characterizing HD\, most studies have focused on the toxic effects elicited by mutant HTT in post-mitotic neurons and the roles of the wild-type protein during development have been overlooked. We will discuss how HTT regulates several steps of mouse embryonic corticogenesis. HTT is crucial to maintain the pool of cycling progenitors and for the migration and post-natal maturation of post-mitotic neurons. We will describe the underlying molecular mechanisms by which HTT mediates its effects. Finally\, we will also show the consequences of the presence of an abnormal polyglutamine expansion in HTT during cortical neurogenesis and consider the viewing of HD as a developmental disorder. \n\nSelected publications\nBarnat M\, Le Friec J\, Benstaali C and Humbert\, S (2017). Huntingtin-mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons is Critical for their Postnatal Neuronal Morphology. Neuron\, 93\, 99-114. \nThion MS\, McGuire JR\, Sousa CM\, Fuhrmann L\, Fitamant J\, Leboucher S\, Vacher S\, Tezenas du Montcel S\, Bièche I\, Bernet A\, Patrick Mehlen P\, Anne Vincent-Salomon A\, and Humbert\, S (2015). Unravelling the role of huntingtin in breast cancer metastasis. J. Natl. Cancer Inst.\, doi: 10.1093/jnci/djv208. \nElias S\, McGuire JR\, Yu H and Humbert S (2015). Huntingtin is required for epithelial polarity through RAB11A mediated apical trafficking of PAR3-aPKC. Plos Biol.\, 13:e1002142. \nMolina-Calavita M\, Barnat M\, Elias S\, Aparicio E\, Piel M and Humbert S (2014). Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex. J. Neurosci.\, 34\, 10034-10040. \nElias S\, Thion MS\, Yu H\, Moreira Sousa C\, Lasgi C\, Morin X and Humbert S (2014). Huntingtin Regulates Mammary Stem Cell Division and Differentiation. Stem Cell Reports\, 2\, 491-506. \n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-sandrine-humbert/
LOCATION:CGFB\, 38 rue Albert Marquet\, Bordeaux\, 33000\, France
CATEGORIES:Séminaire du vendredi
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