BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20210924T113000
DTEND;TZID=Europe/Paris:20210924T123000
DTSTAMP:20260409T164702
CREATED:20210518T115521Z
LAST-MODIFIED:20210915T093413Z
UID:134960-1632483000-1632486600@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire - Frédéric Checler
DESCRIPTION:\n	\n		\n			Venue: Centre Broca Nouvelle-Aquitaine \n\n\n		\n	\n\n	\n		\n			Title\nAlzheimer’s disease etiology: contribution of APP catabolites distinct from canonical Aβ \nAbstract\nAβ has long been at the gravity center of AD pathology. Thus\, the amyloid cascade predicts that Aβ accumulation corresponds to the etiological trigger of the disease. However\, most of clinical assays aimed at preventing Ab formation or neutralizing it after production have failed so far. We showed that besides Aβ\, APP-CTF fragments (namely C99) generated by an enzyme called b-secretase could well contribute to the pathology\, before any Ab detection and independently of Aβ. \nThis seminar will gather recent evidences from our laboratory concerning the early presence of C99 in brain\, its toxic phenotypes including endolysososmal perturbation and mitochondrial defects\, its occurrence in exosomal vesicles and a genetic approach aimed at lowering its production. This seminar will explain the deleterious side-effects observed when targeting g-secretase in vivo\, that could to some extent account for the drastic alterations observed in clinical trials. \nSelected publications\nLAURITZEN\, I .\, PARDOSSI-PIQUARD\, R.\, BAUER\, C.\, BRIGHAM\, E.\, ABRAHAM\, J.D.\, RANALDI\, S.\, FRASER\, P. St-GEORGE-HYSLOP\, P.\, LE THUC\, O.\, ESPIN\, V.\, CHAMI\, L.\, DUNYS\, J. and CHECLER\, F. (2012) The b-secretase-derived C-terminal fragment of b-APP\, C99 but not Ab\, is a key contributor to early intraneuronal lesions in triple transgenic mouse hippocampus. J. Neurosci. 32\, 16243-16255. \nlauritzen\, I.\,  PARDOSSI-PiQUARD\, R.\, BOURGEOIS\, A.\,PAGNOTTA\, S.\, BIFERI\, M-G.\, BARKATS\, M.\, LACOR\, P.\, KLEIN\, W.\, BAUER\, C. and CHECLER F (2016) Intraneuronal aggregation of the b-CTF fragment of APP (C99) induces Ab-independent lysosomal-autophagic pathology. Acta Neuropathol. 132\, 257-276. \nLAURITZEN\, I.\, BECOT\, A.\, BOURGEOIS\, A.\, PARDOSSI-PIQUARD\, R.\, BIFERI\, M-G.\, BARKATS\, M. and CHECLER F. (2019) Targeting g-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models. Translational. Neurodeg. 8\, 35\, doi:10.1186/s40035-019-0176-6 \nVAILLANT-BEUCHOT\, L.\, MARY\, A.\, PARDOSSI-PIQUARD\, R.\, BOURGEOIS\, A.\, LAURITZEN\, I.\, EYSERT\, F.\, KINOSHITA\, P.F.\, CAZARETH\, J.\, BADOT\, C.\, FRAGAKI\, K.\, BUSSIERE\, R.\, MARTIN\, C.\, MARY\, R.\, BAUER\, C.\, PAGNOTTA\, S.\, PAQUIS-FLUCKLINGER\, V.\, BUEE-SCHERRER\, V.\, BUEE\, L.\, LACAS-GERVAIS\, S\, CHECLER F and CHAMI\, M. (2021) Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure\, function and mitophagy defects in Alzheimer’s disease models and human brains . Acta Neuropathologica. 141\, 39-65. \n  \n\nInvited by Gaël Barthet and Christophe Mulle (IINS) \n\n		\n	\n\n	\n		\n			 \n\n		\n	\n\n	\n		\n			Frédéric Checler\n\nUniversité de Nice-Sophia-Antipolis\nInstitut de Pharmacologie Moléculaire et Cellulaire\, CNRS-UMR7275\,\nTeam labeled   « Fondation pour la Recherche Médicale »  et  « Laboratoire d’excellence Distalz »\nSophia-Antipolis\, France\n\nPage web\n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-frederic-checler/
CATEGORIES:A la une,Pour les scientifiques,Séminaire du vendredi
END:VEVENT
END:VCALENDAR