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DTSTART;TZID=Europe/Paris:20200214T113000
DTEND;TZID=Europe/Paris:20200214T123000
DTSTAMP:20260405T191606
CREATED:20191030T135449Z
LAST-MODIFIED:20221130T165759Z
UID:112525-1581679800-1581683400@www.bordeaux-neurocampus.fr
SUMMARY:Séminaire - Chantal Mathis
DESCRIPTION:Lieu : Centre Broca \nEarly memory deficits appearing during preclinical stages in mouse models of Alzheimer disease\n\nChantal Mathis\nChantal Mathis\nDR2 CNRS\, LNCA\, Strasbourg\nhttp://lnca.fr/5.html \nInvited by Nora Abrous (Neurocentre Magendie) \n\nAbstract\nOver the last decade\, the main finding about Alzheimer’s disease (AD) is that initial signs have been detected 15 to 20 years before diagnosis (e.g.\, see Bateman et al\, 2012 and Jack et al\, 2009). Since then\, a great deal of efforts concentrated on the identification of early events and biomarkers that might help us to understand AD pathogenesis. The nature and severity of recognition deficits evolve as AD pathology spreads through medial temporal lobe networks and connected brain structures playing a key role in recognition memories. Therefore\, object recognition paradigms have been useful to determine early memory deficits in animal models of AD. The pertinence of behavioral data provided by these paradigms will be analyzed in regard to the neuropathological phenotype of genetically modified rodent models of AD. Our aim is to outline clear advantages and possible limitations in their translational value. We propose that future progress depends on understanding neural networks supporting each form of recognition memory in parallel with the improvement of animal models of AD. \nSelected publications\nC Mathis (2019) The value of the object recognition paradigm in investigating animal models of Alzheimer’s disease: Advances and future directions\, in. Ennaceur A and de Souza Silva M (Editors)\, Handbook of Object Novelty Recognition\, Volume 26\, Academic Press\, pp. 307-330 ISBN: 9780128120125 \nCès A\, Burg T\, Herbeaux K\, Héraud C\, Bott JB\, Mensah-Nyagan AG\, Mathis C (2018) Age-related vulnerability of pattern separation in C57BL/6J mice. Neurobiol Aging 62:120-129. \nHamm V\, Héraud C\, Bott JB\, Herbeaux K\, Strittmatter C\, Mathis C\, Goutagny R (2017) Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer’s disease. Sci Adv 3(2):e1601068. \n
URL:https://www.bordeaux-neurocampus.fr/event/seminaire-chantal-mathis-2019/
CATEGORIES:A la une,Séminaire du vendredi
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