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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20240331T010000
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DTSTART;TZID=Europe/Paris:20241004T113000
DTEND;TZID=Europe/Paris:20241004T113000
DTSTAMP:20260409T085050
CREATED:20240710T165450Z
LAST-MODIFIED:20240911T213622Z
UID:173117-1728041400-1728041400@www.bordeaux-neurocampus.fr
SUMMARY:PhD seminar - Paulo Pinheiro
DESCRIPTION:Venue: Centre Broca \nPhD seminars are open to everyone!  \n\nPaulo Pinheiro\nPrincipal Investigator\, Center for Neuroscience and Cell Biology\nAssistant Professor\, Department of Life Sciences\nUniversity of Coimbra \nPaulo Pinheiro was a post-doctoral researcher in Christophe Mulle’s team in 2006-2009. \nTitle\nChronic stress impacts synaptic transmission and network activity through miR-186-5p \nAbstract\nChronic stress has significant negative effects on cognitive and emotional behaviors and is a key risk factor for neuropsychiatric disorders. However\, the molecular mechanisms behind these effects remain unclear. Here\, we show that chronic stress triggers the upregulation of miR-186-5p\, which plays a central role in synaptic dysfunction. Increased miR-186-5p levels were observed in both the prefrontal cortex of stressed mice and neurons exposed to dexamethasone. Overexpression of miR-186-5p in mice induced anxiety- and depressive-like behaviors. This upregulation disrupts the balance between glutamatergic and GABAergic transmission and leads to altered network activity\, but can be normalized by a miR-186-5p inhibitor. Our work highlights a new link between chronic stress\, miR-186-5p expression\, and the synaptic changes underlying behavioral and cognitive dysfunction. \nSelected publications\n– Rodrigues\, B.\, Leitão\, R.A.\, Santos\, M. et al. (2024) “MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress”. Molecular Psychiatry doi.org/10.1038/s41380-024-02715-1\n– Tawfik B\, Martins JS\, Houy S\, et al. (2021). Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca 2+-dependent priming. Elife. Mar 22;10:e64527. doi: 10.7554/eLife.64527\n– Gowrisankaran\, S.\, Steubler\, V.\, Houy\, et al. (2020). Endophilin-A controls recruitment\, priming and fusion of neurosecretory vesicles. Nature Communications 11(1):1266 doi: 10.1038/s41467-020-14993-8\n– Silva M.\, Rodrigues\, B.\, Fernandes\, et al. (2019) MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons. PNAS 116(12):5727-5736. doi: 10.1073/pnas.1900338116\n– Vergnano\, A. M.\, Rebola\, N.\, Savtchenko\, L. et al. (2014) Zinc Dynamics and Action at Excitatory Synapses. Neuron 82\, 1101-1114. DOI: 10.1016/j.neuron.2014.04.034\n– Veran\, J.\, Kumar\, J.\, Pinheiro\, P. S.\, et al. (2012) Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface. Neuron 76\, 565-578. DOI: 10.1016/j.neuron.2012.08.027\n– Pinheiro\, P. S.\, Perrais\, D.\, Coussen\, F.\, et al. (2007) GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proceedings of the National Academy of Sciences of the United States of America 104\, 12181-12186. DOI: 10.1073/pnas.0608891104\n\n
URL:https://www.bordeaux-neurocampus.fr/event/phd-seminar-paulo-pinheiro/
CATEGORIES:A la une,Conférences mensuelles,Pour les scientifiques
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