BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261106T113000
DTEND;TZID=Europe/Paris:20261106T113000
DTSTAMP:20261019T084318
CREATED:20260122T092802Z
LAST-MODIFIED:20261013T145536Z
UID:191715-1793964600-1793964600@www.bordeaux-neurocampus.fr
SUMMARY:PhD Seminar - Romain Ligneul
DESCRIPTION:Venue: Centre Broca \nRomain Ligneul\nCenter for Neuroscience Research of Lyon\, France \nTitle\nNovelty\, controllability or uncertainty: emerging properties of serotonergic neurons in the dorsal raphe nucleus \nAbstract\nRecent studies have established that serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) are strongly modulated by a variety of affective and cognitive factors\, thereby challenging monolithic theories of 5-HT function. In this study\, I will first show that DRN 5-HT neurons are strongly modulated by novelty and that their activity modulate specific novelty-related behaviors in mice. Then\, I will describe results from a new cross-species paradigm suggesting that 5-HT neurons encode changes in environmental controllability\, contribute to controllability estimation and participate in the adjustement of downstream foraging strategies in mice and humans. To conclude\, I will discuss the theoretical implications and the clinical relevance of these findings\, with a particular emphasis on anxiety and depression. \nKey publications\nSerotonin\nR Ligneul\, ZF Mainen\nCurrent Biology 33 (23)\, R1216-R1221\nStress-sensitive inference of task controllability \nR Ligneul\, ZF Mainen\, V Ly\, R Cools\nNature Human Behaviour 6 (6)\, 812-822\nDevelopmental shifts in computations used to detect environmental controllability \nHA Raab\, C Foord\, R Ligneul*\, CA Hartley*\nPLoS computational biology 18 (6)\, e1010120 \n
URL:https://www.bordeaux-neurocampus.fr/event/phd-seminar-novembre2026/
CATEGORIES:A la une,Conférences mensuelles,Pour les scientifiques
END:VEVENT
END:VCALENDAR