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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20240331T010000
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DTSTART;TZID=Europe/Paris:20240705T113000
DTEND;TZID=Europe/Paris:20240705T113000
DTSTAMP:20260408T214503
CREATED:20240319T154437Z
LAST-MODIFIED:20240624T094207Z
UID:170160-1720179000-1720179000@www.bordeaux-neurocampus.fr
SUMMARY:Monthly conference (PhD seminar): Agnès Nadjar
DESCRIPTION:Venue: Centre Broca \n\nAgnès Nadjar\nProfessor\, University of Bordeaux\nTeam « Obesity and energy balance » Neurocentre Magendie \nTitle\nNutrient-Driven Microglial Metabolic Reprogramming and its Impact on Mouse Behavior \nAbstract\n\nMicroglia are the brain macrophages\, eliciting multifaceted functions to maintain brain homeostasis across lifetime. To achieve this\, microglia are able to sense a plethora of signals in their close environment. In our research\, we explore the influence of nutrients on microglial function for several reasons: 1) Microglia exhibit all the necessary cellular machinery for nutrient sensing; 2) Dietary patterns have undergone significant changes in the past century\, shifting towards high calorie diets; 3) This so-called “Western diet » correlates with a rise in neuropathologies\, where microglia are recognized to play a substantial role. \nDuring my presentation\, I will share data illustrating how variations in nutrient intake can modify microglial function\, leading to an exacerbation of synaptic pruning. These changes have profound implications for neuronal activity and subsequent behavior. Additionally\, I will present previously undisclosed data shedding light on the mechanisms that underlie the impact of nutrients on microglia\, particularly in the regulation of their metabolic activity. \n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/phd-seminar-agnes-nadjar/
CATEGORIES:A la une,Conférences mensuelles,Pour les scientifiques
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