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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20220511T110000
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UID:147500-1652266800-1652266800@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu Seminar - Frank Schnorrer
DESCRIPTION:Venue: Centre Broca \n\nDo titins rule sarcomeres of insect muscles? \nAbstract\nSarcomeres have a stereotypic architecture across animal species. In mammalian muscles\, sarcomere length is controlled by the large sarcomere ruler titin spanning from the Z-disc to the M-band. Similarly\, non-chordate species such as insects and worms do contain sarcomeres of defined length\, varying only between fiber types. However\, these species do not contain a large titin molecule spanning across a half sarcomere\, hence a simple ruler model cannot generally apply. To investigate how sarcomere length is controlled in non-chordates\, we have manipulated the length and elasticity of the Drosophila titin homolog Sallimus (Sls). In Drosophila larval muscles Sls contains a long PEVK spring domain and extends over 2 µm across the I-band linking the Z-disc to the I-band. Surprisingly\, we find that genetically reducing the spring domain length of Sls not only changes the I-band length\, as expected\, but also reduces the A-band and hence myosin filament length. Hence\, we hypothesize that a biomechanical feedback mechanism controls sarcomere length in non-chordate species. In support of this mechanism\, we have quantified the mechanical forces across Sls in different Drosophila muscle types and find high forces across Sls in sarcomeres with long I-bands\, and lower forces in sarcomeres with shorter I-bands. \n\nFrank Schnorrer\nInstitute for Developmental Biology Marseille \nhttp://muscledynamics.org/ \nInvited by Gregory Giannone \n
URL:https://www.bordeaux-neurocampus.fr/event/impromptu-seminar-frank-schnorrer/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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