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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20110327T010000
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DTSTART:20111030T010000
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DTSTART;VALUE=DATE:20110307
DTEND;VALUE=DATE:20110308
DTSTAMP:20260408T191929
CREATED:20110307T141240Z
LAST-MODIFIED:20201103T124414Z
UID:103593-1299456000-1299542399@www.bordeaux-neurocampus.fr
SUMMARY:HDR - Stefan Clemens
DESCRIPTION:Dopamine function in the spinal cord: its modulatory actions and its relation to restless legs syndrome\n\n\nAbstract :\nThe hypothalamus controls autonomic nervous system function in a large part via strong descending projections to sympathetic preganglionic neurons in the intermediolateral nucleus (IML) of the thoraco-lumbar spinal cord\, including dopaminergic fibers from the A11 region. The A11 region provides the only dopamine (DA) input to the cord\, and DA directly inhibits IML neurons thus limiting sympathetic NS activity. In fact\, many spinal cord-injured individuals\, presumably with impaired DA projections\, express an excess sympathetic activation (e.g. autonomic dysreflexia). DA dysfunction is also likely involved in Restless Legs Syndrome (RLS)\, a common sleep disorder with a strong circadian profile\, but the mechanisms are still unknown. \nDopamine regulates the excitability of monosynaptic and polysynaptic reflex pathways in the thoraco-lumbar cord\, and this modulation is governed in particular via D3 receptor pathways. Moreover\, in animals lacking the D3 receptor (D3KO)\, the DA-induced depression of the reflex is converted into facilitation. Since D3 receptor agonists are particular successful in treating and relieving RLS\, these data suggest that a dysfunction of the D3 receptor signaling pathways might be crucial for the pathophysiological symptoms observed in the clinic. Taken together\, our data indicate that descending DA projections in the spinal cord are under circadian control and that they have important functional consequences on spinal networks both with regard to the somatic nervous system\, as well as to the common output center of the autonomic nervous system. \n\nSelected publications\nS. Clemens\, D.B. Rye\, and S. Hochman (2006)\n Restless Legs Syndrome: Revisiting the dopamine hypothesis from the spinal cord perspective\, Neurology\, in press\n\nS. Clemens\, M.A. Sawchuk\, and S. Hochman (2005)\n Reversal of the circadian expression of tyrosine-hydroxylase but not nitric oxide synthase levels in the spinal cord of D3 receptor knockout mice\, Neuroscience\, 133(2)353-357\n\nS. Clemens and S. Hochman (2004)\n Conversion of the Modulatory Actions of Dopamine on Spinal Reflexes from Depression to Facilitation in D3 Receptor knockout mice\, Journal of Neuroscience 24:11337-11345 \nJury\n\nDenis Combes\, Professeur Universite Bordeaux (président)\nAnsgar Büschges\, Professeur Universite Cologne\nFrancois Clarac\, Directeur de recherches CNRS\, Marseille\nImad Ghorayeb\, MCU et Practicien Hosp\, Universite Bordeaux\nDaniel Zytnicki\, Directeur de recherches CNRS\, Marseille\n\n\n\n\n
URL:https://www.bordeaux-neurocampus.fr/event/hdr-stefan-clemens/
CATEGORIES:HDR
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