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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Paris:20250613T113000
DTEND;TZID=Europe/Paris:20250613T113000
DTSTAMP:20260417T002114
CREATED:20240911T132920Z
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UID:175357-1749814200-1749814200@www.bordeaux-neurocampus.fr
SUMMARY:Friday Seminar - Wataru Inoue
DESCRIPTION:Venue: Centre Broca \n\nWataru Inoue\nWestern University\, Canada\nhttps://www.schulich.uwo.ca/physpharm//people/faculty/inoue_wataru.html \nInvited by Sophie Layé (NutriNeuro) \nTitle\nNeural arithmetic for stress response. \nAbstract\nThe stress response represents a shift in neural operations—from maintaining homeostasis to executing emergency responses—affecting a wide range of behavioral and physiological functions. A classic example is the activation of the hypothalamic-pituitary-adrenal (HPA) axis\, which increases systemic glucocorticoid levels from baseline to stress-elevated concentrations. Despite decades of research\, the neural mechanisms underlying this transition remain poorly understood. \nUsing a combination of in vivo and ex vivo electrophysiology in mice\, along with computational modeling\, we identified a key circuit mechanism that enables rapid transitions in the activity states of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus—critical regulators of the HPA axis. I will present our findings on how local GABAergic feedback circuits tightly constrain the gain (i.e.\, arithmetic transformation) of CRHPVN neurons under non-stress conditions. Stress removes this inhibitory control\, allowing for the robust activation of CRHPVN neurons. Together\, our work reveals a neural arithmetic and circuit-level framework for understanding the hormonal stress response. \n
URL:https://www.bordeaux-neurocampus.fr/event/friday-seminar-wataru-inoue/
CATEGORIES:A la une,Nutrineuro,Pour les scientifiques,Séminaire du vendredi
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