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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20260329T010000
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DTSTART;TZID=Europe/Paris:20260424T113000
DTEND;TZID=Europe/Paris:20260424T113000
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CREATED:20251023T083935Z
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UID:189004-1777030200-1777030200@www.bordeaux-neurocampus.fr
SUMMARY:Friday Seminar - Sylvie Lorthois
DESCRIPTION:Venue: Centre Broca \n\nSylvie Lorthois\nDirectrice de Recherche CNRS\nPorous and Biological Media Group – Institut de Mécanique des Fluides de Toulouse\nwww.imft.fr/ \nInvited by Jean-Luc Morel (INCIA) \nTitle\nIn silico modeling of brain microvascular function to highlight the overlap between cerebrovascular and Alzheimer’s Disease. \nAbstract\nThe cerebral microvascular system is essential to a large variety of physiological processes in the brain\, including blood delivery\, neurotoxic waste clearance and blood flow regulation as a function of neuronal activity (neuro-vascular coupling). It also plays a major role in disease (stroke\, neurodegenerative diseases\, …). However\, the functional consequences of vascular damage (including acute occlusions or long-term remodeling in ageing or disease) are poorly understood. \nIn this context\, in silico modeling approaches are increasingly important\, and enable to integrate the specific multi-scale architecture of the brain microvascular network with the physics of blood flow in confined conditions. I will discuss how the resulting scaling-laws for blood flow and molecular transport are mostly driven by the topology of the microvascular network\, deterministically leading to the emergence of hypoxic pockets in sub-cortical regions under mild hypoperfusion. I will highlight how these results help understand the overlap between cerebrovascular and Alzheimer’s Disease. \n  \n  \n  \n
URL:https://www.bordeaux-neurocampus.fr/event/friday-seminar-sylvie-lorthois/
CATEGORIES:A la une,INCIA,Pour les scientifiques,Séminaire du vendredi
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