BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr
X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20200207T113000
DTEND;TZID=Europe/Paris:20200207T113000
DTSTAMP:20260426T173615
CREATED:20190227T171034Z
LAST-MODIFIED:20200316T133440Z
UID:103776-1581075000-1581075000@www.bordeaux-neurocampus.fr
SUMMARY:Conférence mensuelle (PhD seminar series) - Tara Spires Jones
DESCRIPTION:Vendredi 7 février à 11h30  \nLieu : Centre Broca Nouvelle-Aquitaine \nTara Spires Jones\nPersonal Chair of Neurodegeneration\nDeputy Director of the Centre for Discovery Brain Sciences\nhttps://www.ed.ac.uk/ \nInvitée par Bordeaux Neurocampus et la NBA \n\nAbstract\nSynapse loss correlates strongly with cognitive decline in Alzheimer’s disease\, but the mechanisms underpinning this phenomenon remain unclear. In our group\, we have evidence from mouse models and human post mortem brain tissue implicating pathological proteins in synapse degeneration mediated by interactions between neurons and glia. In a transgenic mouse model of Alzheimer’s disease\, behavioural changes are accompanied by accumulation of amyloid beta and tau in synapses\, increases in inflammatory gene expression\, and phagocytosis of synapses by microglia. When soluble tau levels were lowered\, tau in synapses was reduced and the behavioural phenotype and inflammatory gene expression changes recovered. In human AD brain\, we observe similar accumulations of pathological amyloid beta and tau in synapses\, increases in proteins involved in microglial inflammation\, and increased microglial ingestion of synaptic proteins compared to control brain. Together\, our data implicate pathological protein accumulation in synapses may contribute to synapse phagocytosis by microglia. \nSelected Publications\nTzioras M\, Daniels MJD\, King D\, Popovic K\, Holloway RK\, Stevenson AJ\, Tulloch J\, Kandasamy J\, Sokol D\, Latta C\, Rose J\, Smith C\, Miron VE\, HEnstridge CM\, McColl BW\, Spires-Jones TL (2019) Altered synaptic ingestion by human microglia in Alzheimer’s disease. bioRxiv  https://doi.org/10.1101/795930 \nPickett EK\, Herrmann AG\, McQueen J\, Abt K\, Dando O\, Tulloch J\, Jain P\, Dunnett S\, Sohrabi S\, Fjeldstad MP\, Calkin W\, Murison L\, Jackson RJ\, Tzioras M\, Stevenson A\, d’Orange M\, Hooley M\, Davies C\, Colom-Cadena M\, Anton-Fernandez A\, King D\, Oren I\, Rose J\, McKenzie CA\, Allison E\, Smith C\, Hardt O\, Henstridge CM\, Hardingham GE\, Spires-Jones TL (2019) Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease. Cell Rep 29: 3592-3604 e3595 Doi 10.1016/j.celrep.2019.11.044; \nJackson RJ\, Rose J\, Tulloch J\, Henstridge C\, Smith C\, Spires-Jones TL (2019) Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers. Brain Commun 1: fcz003 Doi 10.1093/braincomms/fcz003; \nHesse R\, Hurtado ML\, Jackson RJ\, Eaton SL\, Herrmann AG\, Colom-Cadena M\, Tzioras M\, King D\, Rose J\, Tulloch J\, McKenzie CA\, Smith C\, Henstridge CM\, Lamont D\, Wishart TM\, Spires-Jones TL (2019) Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype. Acta Neuropathol Commun 7: 214 Doi 10.1186/s40478-019-0847-7; \nHenstridge CM\, Hyman BT\, Spires-Jones TL (2019) Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nat Rev Neurosci 20: 94-108 Doi 10.1038/s41583-018-0113-1 \nAbout the speaker\nProfessor Tara Spires-Jones\, DPhil\nUK Dementia Research Institute Programme Lead\nDeputy Director\, Centre for Discovery Brain Sciences\nThe University of Edinburgh\n\nFounding Editor Brain Communications\nSection Editor European Journal of Neuroscience\nBoard of Reviewing Editors Science\nEditorial Board Member Cell Reports\n\n\nTwitter @TSpiresJones\n\n
URL:https://www.bordeaux-neurocampus.fr/event/conference-mensuelle-tara-spires-jones/
CATEGORIES:A la une,Conférences mensuelles,Pour les scientifiques
END:VEVENT
END:VCALENDAR