{"id":55818,"date":"2018-05-09T18:08:23","date_gmt":"2018-05-09T16:08:23","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/emilie-pacary-olivier-nicole-et-al-in-mol-psychiatry\/"},"modified":"2018-06-19T10:01:48","modified_gmt":"2018-06-19T08:01:48","slug":"emilie-pacary-olivier-nicole-et-al-in-mol-psychiatry","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/emilie-pacary-olivier-nicole-et-al-in-mol-psychiatry\/","title":{"rendered":"Emilie Pacary, Olivier Nicole et al. in <em>Mol Psychiatry<\/em>"},"content":{"rendered":"<p><em><a class=\"external\" href=\"https:\/\/www.nature.com\/articles\/s41380-018-0046-0\"><strong>A novel role for CAMKII\u03b2 in the regulation of cortical neuron migration: implications for neurodevelopmental disorders.<\/strong><\/a>\u00a0Olivier Nicole, Donald M. Bell, Thierry Leste-Lasserre, H\u00e9l\u00e8ne Doat, Fran\u00e7ois Guillemot &amp; Emilie Pacary. Molecular Psychiatry (2018) doi:10.1038\/s41380-018-0046-0<br \/>\n<span class=\"image-wrapper frame floatleft\"><br \/>\n<\/span><strong>Olivier Nicole<\/strong>, CR CNRS in the team \u201cDynamics of neuronal and vascular networks underlying memory processing\u201d (Team leader: Dr Bruno Bontempi). CNRS, UMR5293, Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives.\u00a0<strong>Emilie Pacary,<\/strong>\u00a0CR INSERM in the team \u201cNeurogenesis and pathophysiology\u201d (Team leader: Dr Nora Abrous). INSERM U1215, Neurocentre Magendie.<\/em><\/p>\n<p><strong><span class=\"image-wrapper frame floatleft\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/_contents-images\/ametys-internal%253Asites\/neurosciences\/ametys-internal%253Acontents\/pacary-nicole-molpsy-actualite\/_metadata\/content\/_data\/Pacary_Nicole350.jpg_253x380\" alt=\"\" width=\"380\" height=\"253\" \/><\/span>A series of recent studies indicate that CaMKII dysfunction is associated with a wide variety of psychiatric and neurodevelopmental diseases,<\/strong>\u00a0including depression, schizophrenia, epilepsy and various forms of mental retardation [see review by Robison, Trends Neurosci 37(11):653-62 2014]. CaMKII is a major protein in the brain, accounting for 1-2% of total brain proteins. Because of this abundance and as main player in Ca2+ signaling, CaMKII represents a critical link between the external environment and cellular responses in neurons. Brain CaMKII predominantly consists of the \u03b1 and \u03b2 isoforms, which form heteromeric or homomeric complexes. While the \u03b1 isoform has been studied extensively, probably because of its prominent role in synaptic plasticity, learning, and memory, the isoform-specific functions of CaMKII\u03b2 remain largely unexplored. Yet, perturbation of CaMKII\u03b2 expression, in particular, has been associated with multiple neuropsychiatric diseases, highlighting CaMKII\u03b2 as a gene of interest [see for examples Akita et al., Ann Clin Transl Neurol. 2018; Novak et al., Synapse 59, 61-8 (2006)].<\/p>\n<p>In this study, we reveal a novel isoform-specific function for CaMKII\u03b2 during the development of the cerebral cortex. By using in utero electroporation, we demonstrate that correct levels of CaMKII\u03b2 are essential for proper radial migration of projection neurons. In particular, we show that CaMKII\u03b2 is a critical element not only for the transition between the multipolar and the bipolar stage but also for the saltatory movement of locomoting neurons, two actions which are dependent on its actin-binding and bundling properties. In addition, our data indicate that a fine-tuned balance between CaMKII\u03b2 and cofilin activities is necessary to ensure proper actin remodeling and migration of cortical neurons. Thus, our findings demonstrate that CaMKII\u03b2, by regulating the migration of cortical neurons, contributes to normal brain development and further support an important role for this gene in the pathophysiology of neurodevelopmental disorders.<\/p>\n<h3>Abstract PubMed<\/h3>\n<p>Perturbation of CaMKII\u03b2 expression has been associated with multiple neuropsychiatric diseases, highlighting CaMKII\u03b2 as a gene of interest. Yet, in contrast to CaMKII\u03b1, the specific functions of CaMKII\u03b2 in the brain remain poorly explored. Here, we reveal a novel function for this CaMKII isoform in vivo during neuronal development. By using in utero electroporation, we show that CaMKII\u03b2 is an important regulator of radial migration of projection neurons during cerebral cortex development. Knockdown of CaMKII\u03b2 causes accelerated migration of nascent pyramidal neurons, whereas overexpression of CaMKII\u03b2 inhibits migration, demonstrating that precise regulation of CaMKII\u03b2 expression is required for correct neuronal migration. More precisely, CaMKII\u03b2 controls the multipolar\u2013bipolar transition in the intermediate zone and locomotion in the cortical plate through its actin-binding and -bundling activities. In addition, our data indicate that a fine-tuned balance between CaMKII\u03b2 and cofilin activities is necessary to ensure proper migration of cortical neurons. Thus, our findings define a novel isoform-specific function for CaMKII\u03b2, demonstrating that CaMKII\u03b2 has a major biological function in the developing brain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A novel role for CAMKII\u03b2 in the regulation of cortical neuron migration: implications for neurodevelopmental disorders.<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-55818","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/55818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=55818"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/55818\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=55818"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=55818"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=55818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}