{"id":55063,"date":"2018-05-02T16:47:20","date_gmt":"2018-05-02T14:47:20","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/erc-advanced-grant-fordaniel-choquet\/"},"modified":"2018-06-19T10:10:22","modified_gmt":"2018-06-19T08:10:22","slug":"erc-advanced-grant-fordaniel-choquet","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/erc-advanced-grant-fordaniel-choquet\/","title":{"rendered":"ERC Advanced Grant forDaniel Choquet"},"content":{"rendered":"<div class=\"innertube\">\n<p><a href=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2018\/05\/Choquet-Daniel-800px.jpg\" rel=\"lightbox[55063]\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-55060\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2018\/05\/Choquet-Daniel-800px-300x197.jpg\" alt=\"Daniel Choquet\" width=\"300\" height=\"197\" \/><\/a>After <strong><em>Nano-Dyn-Syn<\/em><\/strong> in 2009 and <strong><em>ADOS\u00a0<\/em> in<\/strong> 2014, <strong>Daniel Choquet has been granted for its research project called Dyn-Syn-Mem.<\/strong><\/p>\n<h2>About the research<\/h2>\n<p><strong>Activity-dependent plasticity<\/strong>\u00a0of synaptic transmission together with refinement of neural circuits connectivity are amongst the core mechanisms underlying learning and memory. While there is already extensive knowledge on some of the mechanisms of synaptic plasticity, fundamental questions remain on the dynamics of the underlying molecular events and the functional roles of various forms of synaptic plasticity in information processing, learning and behavior.<\/p>\n<p><strong>We previously uncovered<\/strong>\u00a0basic features of glutamate receptor movements and their role in excitatory synaptic transmission. Our new ground-breaking objectives are: 1) to uncover, in a physiological context, the dynamic mechanisms through which synapses modulate their strength in response to neuronal activity by integrating on different space and time scales the properties of receptor traffic pathways and associated stabilization mechanisms, 2) to use our knowledge and innovative tools to interfere with these trafficking mechanisms in order to decipher the specific roles of different forms of synaptic plasticity in given brain functions and behavioral tasks. For this aim, I lead a team of neurobiologists, physicists and chemists with a collaborative record of accomplishment. We will combine imaging, cellular neurobiology, physiology and behavior to probe the mechanisms and roles of different forms of synaptic plasticity.<\/p>\n<p><strong>New in tissue high-resolution imaging combined<\/strong>\u00a0with innovative molecular reporters and electrophysiology will allow analysis of receptor traffic during short and long-term synaptic plasticity in physiological conditions. We will probe the interplay between activity-dependent changes in synaptic strength and circuit function with new photo-activable modifiers of receptor traffic with an unprecedented time and space resolution. Use of these tools in vivo will allow identifying the roles of synaptic plasticity in sensory information processing and the various phases of spatial memory formation.<\/p>\n<\/div>\n<p class=\"content-contact\"><a href=\"mailto:daniel.choquet@u-bordeaux.fr\">Daniel Choquet IINS, UMR 5297 CNRS &#8211; Universit\u00e9 de Bordeaux &#8211; Institut Interdisciplinaire de NeuroScience BIC, UMS 3420 CNRS-US 004 INSERM-Universit\u00e9 de Bordeaux Bordeaux Imaging Center<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Daniel Choquet, DR CNRS \u00e0 l\u2019Institut interdisciplinaire de neurosciences (IINS), est laur\u00e9at pour la 3\u00e8me fois d&#8217;un ERC Advanced Grant d\u00e9cern\u00e9 par le Conseil Europ\u00e9en de la Recherche (ERC). <\/p>\n","protected":false},"author":108,"featured_media":147015,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[91,1],"tags":[],"class_list":["post-55063","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-awards","category-news-neurocampus"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/55063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=55063"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/55063\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/147015"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=55063"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=55063"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=55063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}