{"id":208224,"date":"2026-10-22T11:47:41","date_gmt":"2026-10-22T09:47:41","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=208224"},"modified":"2026-10-22T11:56:38","modified_gmt":"2026-10-22T09:56:38","slug":"hypothalamic-pomc-neurons-gate-the-fear-feeding-trade-off","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/hypothalamic-pomc-neurons-gate-the-fear-feeding-trade-off\/","title":{"rendered":"Hypothalamic POMC Neurons Gate the Fear-Feeding Trade-Off"},"content":{"rendered":"<div>Cristina Miralpeix (Cota team) and Abel Eraso-Pichot (Marsicano team), from the Neurocentre Magendie (Univ. Bordeaux \/ Inserm), have just published a study in Advanced Science on how the brain arbitrates between feeding and staying safe. When confronted with potential threats, hungry animals must continually arbitrate between feeding and defensive behaviors. The authors show that hypothalamic POMC neurons engage CRH-expressing stress circuits and downstream hormonal responses to coordinate the selection between these competing behaviors. CB1 receptor signaling in POMC neurons modulates this process, biasing behavior toward defensive responses over feeding.<\/div>\n<h2>Article<\/h2>\n<div>\n<p class=\"heading-title\"><em><strong>Hypothalamic POMC Neurons Gate the Fear-Feeding Trade-Off<\/strong><\/em><\/p>\n<p>Cristina Miralpeix<sup>#1<\/sup> ,\u00a0Abel Eraso-Pichot\u00a0<sup>#1<\/sup>,\u00a0Vincent Simon<sup>1<\/sup>,\u00a0Victor Jouque<sup>1<\/sup>,\u00a0Melissa Sadallah<sup>1<\/sup> ,\u00a0Samantha Clark<sup>1<\/sup>,\u00a0Philippe Zizzari<sup>1<\/sup>,\u00a0Urszula Skupio<sup>1<\/sup> ,\u00a0Ana Covelo<sup>1<\/sup> ,\u00a0Nathalie Dupuy<sup>1<\/sup>,\u00a0Jean Charles Nicolas<sup>1<\/sup> ,\u00a0Astrid Cannich<sup>1<\/sup>,\u00a0Thierry Leste-Lasserre<sup>1<\/sup>,\u00a0Guillaume Laplagne<sup>1<\/sup>,\u00a0Carmelo Quarta<sup>1<\/sup>,\u00a0Giovanni Marsicano<sup>1<\/sup>,\u00a0Daniela Cota<sup>1<\/sup><\/p>\n<p><sup class=\"key\">1<\/sup> University of Bordeaux, INSERM, Neurocentre Magendie, U1215, Bordeaux, France.<br \/>\n<sup class=\"key\">#<\/sup> Contributed equally.<br \/>\ndoi: 10.1002\/advs.78379<\/p>\n<p><a href=\"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78379\" target=\"_blank\" rel=\"noopener\">https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78379<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cristina Miralpeix, Abel Eraso-Pichot et al in Advanced Science<\/p>\n","protected":false},"author":108,"featured_media":208225,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-208224","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/208224","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=208224"}],"version-history":[{"count":1,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/208224\/revisions"}],"predecessor-version":[{"id":208226,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/208224\/revisions\/208226"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/208225"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=208224"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=208224"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=208224"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}