{"id":207237,"date":"2026-10-09T11:10:10","date_gmt":"2026-10-09T09:10:10","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=207237"},"modified":"2026-10-09T11:11:37","modified_gmt":"2026-10-09T09:11:37","slug":"postdoctoral-position-development-of-polymer-vesicles-for-detoxification-in-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/postdoctoral-position-development-of-polymer-vesicles-for-detoxification-in-parkinsons-disease\/","title":{"rendered":"Postdoctoral position: Development of polymer vesicles for detoxification in Parkinson\u2019s disease"},"content":{"rendered":"<p><strong>Project description<\/strong><\/p>\n<p>This postdoctoral position is part of the NANOTRAP project, which brings together the Laboratoire de chimie des polym\u00e8res organiques (LCPO) and the NutriNeuro laboratory at the interface of polymer physical chemistry, biochemistry, and neuroscience. The project explores a nanomedicine approach aimed at limiting the accumulation of toxic compounds involved in neurodegeneration, particularly in Parkinson\u2019s disease. It focuses on developing polymer vesicles, known as polymersomes, capable of encapsulating enzymes and acting as nanoreactors for cellular detoxification.<\/p>\n<p>The successful candidate will develop and characterize these polymer vesicles, optimize enzyme encapsulation, and evaluate their functional properties. They will also investigate their behavior in biological environments in vitro. This work will explore the potential of these systems in cellular models of neurodegenerative diseases, with a particular focus on Parkinson\u2019s disease.<\/p>\n<p><strong>R\u00e9f\u00e9rences<\/strong><\/p>\n<ol>\n<li>Martin, A.; et al. <em> J. Pharm.<\/em> <strong>2023<\/strong>, 642, 123157, <a href=\"https:\/\/doi.org\/10.1016\/j.ijpharm.2023.123157\">https:\/\/doi.org\/10.1016\/j.ijpharm.2023.123157<\/a>.<\/li>\n<li>Schvartzman, C.; et al. <em>Biomacromolecules<\/em> <strong>2024<\/strong>, 25 (7), 4087\u20134094. <a href=\"https:\/\/doi.org\/10.1021\/acs.biomac.4c00200\">https:\/\/doi.org\/10.1021\/acs.biomac.4c00200<\/a>.<\/li>\n<li>Marie, A.; et al. <em> Nutr.<\/em> <strong>2022<\/strong>, 9, 811843. <a href=\"https:\/\/doi.org\/10.3389\/fnut.2022.811843\">https:\/\/doi.org\/10.3389\/fnut.2022.811843<\/a>.<\/li>\n<li>Bosch-Bouju, C.; et al. <em> Neurosci.<\/em> <strong>2014<\/strong>, 34 (48), 15836\u201315850. <a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.0893-14.2014\">https:\/\/doi.org\/10.1523\/JNEUROSCI.0893-14.2014<\/a>.<\/li>\n<li>Baufeld, C.; et al. <em> Neural Transm.<\/em> <strong>2018<\/strong>, 125 (5), 809\u2013826. <a href=\"https:\/\/doi.org\/10.1007\/s00702-017-1795-7\">https:\/\/doi.org\/10.1007\/s00702-017-1795-7<\/a>.<\/li>\n<\/ol>\n<p><strong>Techniques used<\/strong><\/p>\n<ul>\n<li>Nano- and microparticle formulation and enzyme encapsulation. Characterization by dynamic light scattering (DLS), electron microscopy, or fluorescence microscopy.<\/li>\n<li>High-performance liquid chromatography (HPLC) and enzyme activity assays.<\/li>\n<li>2D and 3D cell culture, viability assays, and immunofluorescence analysis.<\/li>\n<\/ul>\n<p><strong>Candidate profile and internship conditions<\/strong><\/p>\n<p>The candidate should hold a PhD in materials science applied to healthcare or in cell biology applied to neuroscience. Experience in developing materials for biological applications would be particularly welcome. A strong interest in research at the interface of chemistry and neuroscience, together with the ability to work in an interdisciplinary environment, is expected.<\/p>\n<p><strong>Start date:<\/strong> December 1<sup>st<\/sup> , 2026<\/p>\n<p><strong>Contract duration:<\/strong> 16 months<\/p>\n<p><strong>Laboratories: <\/strong><\/p>\n<p>LCPO, ENSCBP, 16 avenue Pey Berland, 33607 Pessac, France<\/p>\n<p>NutriNeuro, UMR 1286, 146 rue L\u00e9o Saignat, 33076 Bordeaux, France<\/p>\n<p><strong>Contacts<\/strong><\/p>\n<p>Dr Angela Mutschler, LCPO, <a href=\"mailto:angela.mutschler@u-bordeaux.fr\">angela.mutschler@u-bordeaux.fr<\/a><\/p>\n<p>Dr Cl\u00e9mentine Bosch-Bouju, NutriNeuro, <a href=\"mailto:clementine.bosch-bouju@inrae.fr\">clementine.bosch-bouju@inrae.fr<\/a><\/p>\n<p>Dr Charlotte Madore-Delpech, NutriNeuro, <a href=\"mailto:charlotte.madore-delpech@inrae.fr\">charlotte.madore-delpech@inrae.fr<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project description This postdoctoral position is part of the NANOTRAP project, which brings together the Laboratoire de chimie des polym\u00e8res organiques (LCPO) and the NutriNeuro laboratory at the interface of polymer physical chemistry, biochemistry, and neuroscience. The project explores a nanomedicine approach aimed at limiting the accumulation of toxic compounds involved in neurodegeneration, particularly in Parkinson\u2019s disease. It focuses on developing polymer vesicles, known as polymersomes, capable of encapsulating enzymes and acting as nanoreactors for cellular detoxification. The successful candidate will develop and characterize these polymer vesicles, optimize enzyme encapsulation, and evaluate their functional properties. They will also investigate their&hellip;<\/p>\n","protected":false},"author":108,"featured_media":153715,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[201],"tags":[],"class_list":["post-207237","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-position"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/207237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=207237"}],"version-history":[{"count":1,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/207237\/revisions"}],"predecessor-version":[{"id":207238,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/207237\/revisions\/207238"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/153715"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=207237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=207237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=207237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}