{"id":20684,"date":"2015-01-12T14:58:25","date_gmt":"2015-01-12T13:58:25","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/matthieu-bastide-erwan-bezard-dans-biological-psychiatry\/"},"modified":"2018-04-09T10:41:04","modified_gmt":"2018-04-09T08:41:04","slug":"matthieu-bastide-erwan-bezard-dans-biological-psychiatry","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/matthieu-bastide-erwan-bezard-dans-biological-psychiatry\/","title":{"rendered":"Matthieu Bastide, Erwan B\u00e9zard dans <em>Biological Psychiatry<\/em>"},"content":{"rendered":"<p class=\"news-date\">January 12, 2015<\/p>\n<div class=\"innertube\">\n<div class=\"content-illustration\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/_contents-images\/ametys-internal%253Asites\/neurosciences\/ametys-internal%253Acontents\/e-bezard-biol-psy-actualite\/_metadata\/illustration\/image_max0x180\/Habenula.jpg?objectId=defaultWebContent:\/\/785aeec0-15f2-4f38-91fd-cf90623a197a\" alt=\"\" \/><\/div>\n<p><strong><em>Inhibiting Lateral Habenula Improves L-DOPA-induced Dyskinesia.<\/em><\/strong><br \/>\n<em>Bastide MF, de la Crompe B, Doudnikoff E, Fernagut PO, Gross CE, Mallet N, Boraud T, B\u00e9zard E.<br \/>\nBiol Psychiatry. 2014 Sep 9. pii: S0006-3223(14)00674-X. doi: 10.1016\/j.biopsych.2014.08.022<\/em><\/p>\n<hr \/>\n<p><span class=\"image-wrapper frame floatleft\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/_contents-images\/ametys-internal%253Asites\/neurosciences\/ametys-internal%253Acontents\/e-bezard-biol-psy-actualite\/_metadata\/content\/_data\/BezardE130.jpg_187x130\" alt=\"\" width=\"130\" height=\"187\" \/><\/span><\/p>\n<p>Inhibiting Lateral Habenula improves L-Dopa induced dyskinesia We previously identified the Lateral Habenula (LHb) as potentially involved in L-dopa-induced dyskinesia (LID) based on its strong transcriptional response to L-Dopa in dyskinetic rats, as shown with an overexpression of \u2206FosB, ARC and Zif268 (Bastide et al., Neurobiol Dis (2014);62:179-192). Interestingly, in the early 90\u2019s, 2-deoxyglucose (2-DG) seminal studies showed that LHb stood up as a strongly affected non-basal ganglia nucleus displaying a dramatic increase in 2-DG accumulation in parkinsonism (Mitchell et al., Neuroscience (1989);32:213-226). To investigate the role of LHb neurons in LID, <strong><a class=\"simple\" href=\"https:\/\/www.bordeaux-neurocampus.fr\/fr\/publications\/highlights\/highlights-2014\/p-o-fernagut.html\">we used the daun02 inactivation method<\/a><\/strong> . In this study, we demonstrate that LHb displayed a LID-related pathological activity at different functional levels including metabolic, electrophysiological and \u2206FosB-related transcriptional readouts.<\/p>\n<p>Altogether, those data demonstrate that LHb neuronal activity in response to L-Dopa is related to LID manifestation. We show that firing frequency of LHb neurons significantly increased in dyskinetic rats, together with an increased expression of the dopaminergic D1 receptor in \u2206FosB-positive neurons.<\/p>\n<p>Then, using Daun02-driven inactivation, we demonstrate that the selective silencing of LHb \u2206FosB-expressing neurons both alleviates LID severity and enhances the L-Dopa antiparkinsonian action, indicating an involvement of LHb both in LID expression and in the antiparkinsonian effect of L-Dopa. Taken altogether our results highlight a key role of LHb in the genesis of dyskinesia manifestation outside of the basal ganglia.<\/p>\n<p class=\"content-contact\"><a href=\"mailto:erwan.bezard@u-bordeaux.fr\">Erwan B\u00e9zard: Director of IMN<\/a><\/p>\n<h2 class=\"content-contact\">1er auteur<\/h2>\n<p><span class=\"image-wrapper frame\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/_contents-images\/ametys-internal%253Asites\/neurosciences\/ametys-internal%253Acontents\/e-bezard-biol-psy-article\/_metadata\/content\/_data\/Bastide-M.jpg_230x160\" alt=\"\" width=\"160\" height=\"230\" \/><\/span><em><strong>Matthieu F Bastide<\/strong> defended his thesis in septembre 2014 in the team of Christian Gross.<br \/>\n<\/em><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<hr \/>\n<\/div>\n<p><strong>Lastupdate: 2015.01.14<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inhibiting Lateral Habenula Improves L-DOPA-induced Dyskinesia.<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-20684","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=20684"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20684\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=20684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=20684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=20684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}