{"id":20680,"date":"2015-01-28T14:51:04","date_gmt":"2015-01-28T13:51:04","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/nicole-mons-et-al-inhippocampus\/"},"modified":"2018-04-09T10:41:14","modified_gmt":"2018-04-09T08:41:14","slug":"nicole-mons-et-al-inhippocampus","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/nicole-mons-et-al-inhippocampus\/","title":{"rendered":"Nicole Mons et al. inHippocampus<\/em>"},"content":{"rendered":"

January 28th, 2015<\/p>\n

\"\"<\/div>\n

Post-training, intra-hippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice<\/a>.<\/strong> Dagnas M, Micheau J, Decorte L, Beracochea D, Mons N. Hippocampus. 2014 Dec 19. doi: 10.1002\/hipo.22406.<\/em><\/p>\n

\n


\nAlthough studies of memory formation and consolidation have emphasized the importance of multiple intracellular signaling cascades and transcription factors,<\/strong> it has become clear that epigenetic events play a critical role throughout the modulation of plasticity\/memory-related gene expression. Of the various epigenetic modifications, the acetylation of histone proteins on their N-terminal tails via histone acetyltransferases has emerged as a transcriptionally permissive mark. This process causes chromatin structure to relax, leading to enhanced transcription, and can be reversed by histone deacetylases (HDACs). Pre-training treatments with HDAC inhibitors (HDACi) improve hippocampus-dependent learning and memory in young \u201chealthy\u201d rodents and ameliorate or restore memory functions in aged rodents as well as in different neurodegenerative models. Enhanced memory consolidation after post-training HDAC blockade was also observed in young rodents. However, whether such treatment is sufficient to prevent age-associated memory impairments remains largely unclear. In the present work, we demonstrate that post-training injection of nonselective HDACi trichostatin A (TSA) into the dorsal hippocampus improved long-term spatial memory in young-adults, but fails to rescue memory impairments in older mice.<\/p>\n

Using a one-day massed spatial learning task in the water maze, we show that local, intra-hippocampal HDAC blockade in young mice induces histone hyperacetylation in the dorsal hippocampus together with an increase in the dorsomedial part of the striatum (DMS), a structure important for spatial information processing. Importantly, HDAC blockade completely reversed age-associated reduced histone acetylation in the dorsal hippocampus but failed to rescue altered histone acetylation in the DMS. Additionally, we show that intra-hippocampal HDAC blockade produced concomitant decreases (in young-adults) or increases (in older mice) of acetylated histone levels in structures critically involved in stress and emotional responses.<\/p>\n

Taken altogether, these results highlight a key role for histone acetylation-deacetylation balance in the regulation of network plasticity during memory processes and further suggest that age-associated memory impairments may be related to an inability to recruit appropriate circuit-specific epigenetic patterns during consolidation processes.<\/p>\n

\"\"
\n<\/span>
\n\"\"<\/span><\/strong>Nicole Mons<\/em><\/strong>
\nCharg\u00e9 de Recherches CNRS (CR1), HDR<\/em>
\nCNRS UMR 5287 – INCIA<\/em>
\nTeam: Interactions between emotions and memory systems: from normal to pathological aging. Daniel Beracochea <\/em>
\nDomain: Cognition and behaviour \/ Animal cognition and behaviour<\/em><\/p>\n

Nicole Mons<\/a><\/p>\n

Derni\u00e8re mise \u00e0 jour le 29.01.2015<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Post-training, intra-hippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice.<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-20680","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=20680"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20680\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=20680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=20680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=20680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}