{"id":20595,"date":"2015-06-10T17:21:27","date_gmt":"2015-06-10T15:21:27","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/b-dehay-m-bourdenx-et-al-in-lancet-neurol\/"},"modified":"2018-04-05T17:26:13","modified_gmt":"2018-04-05T15:26:13","slug":"b-dehay-m-bourdenx-et-al-in-lancet-neurol","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/b-dehay-m-bourdenx-et-al-in-lancet-neurol\/","title":{"rendered":"B. Dehay, M. Bourdenx et al. in <em>Lancet Neurol.<\/em>"},"content":{"rendered":"<p class=\"news-date\">Le 10 juin 2015<\/p>\n<p><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/_contents-images\/ametys-internal%253Asites\/neurosciences\/ametys-internal%253Acontents\/bdehay-lancet-neurol-actualite\/_metadata\/illustration\/image_max0x180\/ParkinDehay.jpg?objectId=defaultWebContent:\/\/8511215e-ae22-463c-89c4-b98a72700449\" alt=\"\" \/><a class=\"external\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26050140\"><strong><em>Targeting \u03b1-synuclein for treatment of Parkinson\u2019s disease: mechanistic and therapeutic considerations<\/em><\/strong><\/a><br \/>\n<em>Benjamin Dehay*, Mathieu Bourdenx*, Philippe Gorry, Serge Przedborski, Miquel Vila, St\u00e9phane Hunot, Andrew Singleton, C Warren Olanow, Kalpana M Merchant, Erwan Bezard, Gregory A Petsko, Wassilios G Meissner<\/em><br \/>\n<em>dans The Lancet Neurology (Published Online June 4, 2015 ; Impact Factor: 21.823) Review (Personal View)<\/em><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p><strong><span lang=\"en\">Abstract PubMed<\/span> :<br \/>\n<\/strong><em>Progressive neuronal cell loss in a small subset of brainstem and mesencephalic nuclei and widespread aggregation of the \u03b1-synuclein protein in the form of Lewy bodies and Lewy neurites are neuropathological hallmarks of Parkinson\u2019s disease. Most cases occur sporadically, but mutations in several genes, including SNCA, which encodes \u03b1-synuclein, are associated with disease development. The discovery and development of therapeutic strategies to block cell death in Parkinson\u2019s disease has been limited by a lack of understanding of the mechanisms driving neurodegeneration. However, increasing evidence of multiple pivotal roles of \u03b1-synuclein in the pathogenesis of Parkinson\u2019s disease has led researchers to consider the therapeutic potential of several strategies aimed at reduction of \u03b1-synuclein toxicity. We critically assess the potential of experimental therapies targeting \u03b1-synuclein, and discuss steps that need to be taken for target validation and drug development.<\/em><strong><br \/>\n<\/strong><\/p>\n<p><a href=\"https:\/\/www.bordeaux-neurocampus.fr\/en\/b-dehay-m-bourdenx-et-al-in-lancet-neurol\/\">More information in french<\/a><\/p>\n<p class=\"content-contact\"><a href=\"mailto:erwan.bezard@u-bordeaux.fr\">Institute of Neurodegenerative Diseases, University of Bordeaux <\/a><\/p>\n<p class=\"lastupdate\"><strong>Last update: 06.10.2015<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Targeting \u03b1-synuclein for treatment of Parkinson\u2019s disease: mechanistic and therapeutic considerations<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-20595","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=20595"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20595\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=20595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=20595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=20595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}